Maxp1 antibody, NORE1 antibody, NORE1A antibody, NORE1B antibody, RAPL antibody, RASSF3 antibody, 1300019G20Rik antibody, AU042887 antibody, Nore1 antibody, Nore1A antibody, Nore1B antibody, Rapl antibody, Ras association domain family member 5 antibody, Ras association (RalGDS/AF-6) domain family member 5 antibody, RASSF5 antibody, Rassf5 antibody
背景
Rassf5 is a potental tumor suppressor. It seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. It may be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis. Alias Symbols: 1300019G20Rik, AU042887, Maxp1, Nore1, Nore1A, Nore1B, Rapl Protein Interaction Partner: Hras, Protein Size: 413