USP20 抗体 (Middle Region)
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北京 101111
Quick Overview for USP20 抗体 (Middle Region) (ABIN2788022)
抗原
See all USP20 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- USP20 Antibody - middle region
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序列
- PAEAQPPSPR SSSPCRTPEP DNDAHLRSSS RPCSPVHHHE GHAKLSSSPP
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预测反应
- Cow: 92%, Dog: 92%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 85%, Rabbit: 100%, Rat: 92%
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产品特性
- This is a rabbit polyclonal antibody against USP20. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human USP20
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anti-Ubiquitin Specific Peptidase 20 (USP20) (AA 814-844), (C-Term) antibody
USP20 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB4351 unconjugated
anti-Ubiquitin Specific Peptidase 20 (USP20) (Internal Region) antibodyUSP20 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 20 (USP20) (Internal Region) antibodyUSP20 适用: 人, 犬, 兔, 马, 小鸡, Cow, Pig, 猴, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 20 (USP20) (Internal Region) antibodyUSP20 适用: 人, 犬, 兔, 马, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 20 (USP20) (C-Term) antibodyVerified USP20 适用: 人 ELISA, WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 20 (USP20) (AA 361-410) antibodyUSP20 适用: 人, 大鼠, 兔, 小鸡, 猴, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 20 (USP20) (AA 863-913) antibodyUSP20 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 20 (USP20) (AA 252-349) antibodyUSP20 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1A6 unconjugated
anti-Ubiquitin Specific Peptidase 20 (USP20) (AA 1-913) antibodyUSP20 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 20 (USP20) (AA 1-913) antibodyUSP20 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59314-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
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别名
- USP20
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背景
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Background Information: USP20 is a deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. USP20 deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity.USP20 mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Gene Name: Ubiquitin specific peptidase 20
Alternative Symbols: VDU2, hVDU2, LSFR3A
Protein Name: Ubiquitin carboxyl-terminal hydrolase 20
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分子量
- 102kDa
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基因ID
- 10868
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NCBI登录号
- NP_006667
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UniProt
- Q9Y2K6
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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