UCHL3 抗体 (Middle Region)
Quick Overview for UCHL3 抗体 (Middle Region) (ABIN2788014)
抗原
See all UCHL3 (Uchl3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- IHAIANNKDK MHFESGSTLK KFLEESVSMS PEERAKFLEN YDAIRVTHET
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预测反应
- Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 83%
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产品特性
- This is a rabbit polyclonal antibody against Uchl3. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of Mouse Uchl3
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anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (AA 131-230) antibody
Uchl3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E9 unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (AA 195-225), (C-Term) antibodyUchl3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4187 unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (AA 195-225) antibodyUchl3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (AA 1-220) antibodyUchl3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) antibodyUchl3 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (AA 1-220), (C-Term) antibodyUchl3 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (AA 131-230) antibodyUchl3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (N-Term) antibodyUchl3 适用: 人, 大鼠, 小鼠, Cow, 马, 犬, 兔, 豚鼠, 斑马鱼, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (C-Term) antibodyUchl3 适用: 人, 大鼠, 小鼠, Cow, 马, 犬, 兔, Pig, 猴, Hamster IHC, IHC (p), IF, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3) (Internal Region) antibodyUchl3 适用: 人, 大鼠, 小鼠, 犬, 小鸡 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 230 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))
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别名
- Uchl3
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背景
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Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Uchl3 has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Uchl3 deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Uchl3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response retinal, skeletal muscle and germ cell maintenance. Uchl3 may be involved in working memory and can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.
Alias Symbols: -
Protein Interaction Partner: Nedd8,
Protein Size: 230 -
分子量
- 26 kDa
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基因ID
- 50933
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NCBI登录号
- NM_016723, NP_057932
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UniProt
- Q9JKB1
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途径
- Feeding Behaviour, Positive Regulation of fat Cell Differentiation
抗原
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