ATF5 抗体 (Middle Region)
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北京 101111
Quick Overview for ATF5 抗体 (Middle Region) (ABIN2787491)
抗原
See all ATF5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- ATF5 Antibody - middle region
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序列
- LPPPQQPPPP SPPQPSRLAP YPHPATTRGD RKQKKRDQNK SAALRYRQRK
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 93%
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产品特性
- This is a rabbit polyclonal antibody against ATF5. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human ATF5
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57977-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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: "Cdc34-mediated degradation of ATF5 is blocked by cisplatin." in: The Journal of biological chemistry, Vol. 283, Issue 27, pp. 18773-81, (2008) (PubMed).
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- ATF5 (Activating Transcription Factor 5 (ATF5))
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别名
- ATF5
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背景
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Background Information: ATF5 belongs to the bZIP family. It is transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Loss of ATF5 is associated with hepatocellular carcinoma.
Gene Name: Activating transcription factor 5
Alternative Symbols: ATFX, HMFN0395
Protein Name: Cyclic AMP-dependent transcription factor ATF-5
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分子量
- 31kDa
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基因ID
- 22809
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NCBI登录号
- NP_036200
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UniProt
- B3KND3
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途径
- Myometrial Relaxation and Contraction
抗原
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