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MBP 抗体 (Middle Region)

Name: MBP 抗体 (Middle Region)
SKU: ABIN2786586
Availability: OutOfStock

MBP 适用: 人, 小鼠, 大鼠, Cow, Pig, 兔, 豚鼠, 马, 犬 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-MBP Antibody Titration: 0. (MBP 抗体 (Middle Region))

IP Suggested Anti-MBP Antibody Positive Control: NT2 CELL/BRAIN TISSUE (MBP 抗体 (Middle Region))

2 images

产品编号 ABIN2786586

发货至: 中国

Datasheet as PDF

抗原 See all MBP 抗体

MBP (Myelin Basic Protein (MBP))
抗原表位
20

10

6

5

4

3

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Middle Region
适用
116

34

32

20

11

9

8

6

6

5

4

4

3

3

2

1

1

1
人, 小鼠, 大鼠, Cow, Pig, 兔, 豚鼠, 马, 犬
宿主
77

36

9

6

1

1
兔
Compatible Secondaries
克隆类型
78

49

1
多克隆
标记
88

9

6

3

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MBP antibody is un-conjugated
应用范围
78

46

43

16

15

14

14

8

7

6

6

6

5

3

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

序列

FGGDRGAPKR GSGKDSHHPA RTAHYGSLPQ KSHGRTQDEN PVVHFFKNIV

预测反应

Cow: 80%, Dog: 87%, Guinea Pig: 79%, Horse: 80%, Human: 100%, Mouse: 93%, Pig: 80%, Rabbit: 93%, Rat: 87%

产品特性

This is a rabbit polyclonal antibody against MBP. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the middle region of human MBP

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anti-Myelin Basic Protein (MBP) (AA 135-190) antibody
MBP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Myelin Basic Protein (MBP) antibody
MBP 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Myelin Basic Protein (MBP) (AA 150-250) antibody
MBP 适用: 人 IHC 宿主: 兔 Monoclonal MSVA-390R unconjugated Recombinant Antibody

anti-Myelin Basic Protein (MBP) (AA 182-197), (C-Term) antibody
MBP 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Myelin Basic Protein (MBP) (AA 220-301) antibody
MBP 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Myelin Basic Protein (MBP) (AA 18-222) antibody
MBP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Myelin Basic Protein (MBP) (AA 182-197) antibody
MBP 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Myelin Basic Protein (MBP) (AA 82-87) antibody
MBP 适用: 人, 小鼠, 大鼠, Cow, Pig, 兔, 豚鼠, 绵羊, 小鸡, 哺乳动物 WB, ELISA, IF, RIA 宿主: 大鼠 Monoclonal 12 unconjugated

anti-Myelin Basic Protein (MBP) (AA 84-89) antibody
MBP 适用: 人 IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal 22 unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 304 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

MBP (Myelin Basic Protein (MBP))

别名

Myelin basic protein (MBP 产品)

背景

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. MBP induces T-cell proliferation.The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
Alias Symbols: MGC99675
Protein Interaction Partner: CTDSP1, MAP3K3, UBC, PRKCB, MAPK3, MAPK1, ULK1, SQSTM1, PKN1, HIPK2, MNAT1, CDK9, CDK8, CDK7, CCNT1, CCNH, CCNC, MELK, DDX58, MAPK14, AT4G38520, AT4G31860, AT4G28400, ABI1, RPS6KA6, TOPP8, AT5G24940, AT5G10740, AT5G06750, AT3G17250, AT3G02750, AT3G15260,
Protein Size: 304

分子量

33 kDa

基因ID

4155

NCBI登录号

NM_001025101, NP_001020272

UniProt

P02686