AKTIP 抗体 (Middle Region)
(1 reference)Quick Overview for AKTIP 抗体 (Middle Region) (ABIN2786570)
抗原
See all AKTIP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- NPSVHDEARE KMLTQKKPEE QHNKSVHVAG LSWVKPGSVQ PFSKEEKTVA
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 83%
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产品特性
- This is a rabbit polyclonal antibody against AKTIP. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human AKTIP
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anti-AKT Interacting Protein (AKTIP) (AA 1-292) antibody
AKTIP 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-AKT Interacting Protein (AKTIP) (AA 1-292) antibodyAKTIP 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A11 unconjugated
anti-AKT Interacting Protein (AKTIP) (AA 1-292) antibodyAKTIP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-AKT Interacting Protein (AKTIP) (AA 201-292) antibodyAKTIP 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-AKT Interacting Protein (AKTIP) (AA 1-292) antibodyAKTIP 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-AKT Interacting Protein (AKTIP) (AA 1-292) antibodyAKTIP 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B2 unconjugated
anti-AKT Interacting Protein (AKTIP) (AA 1-292) antibodyAKTIP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-AKT Interacting Protein (AKTIP) (C-Term) antibodyAKTIP 适用: 人, 小鼠, 大鼠, 犬, 兔, 斑马鱼, Cow, 豚鼠, 马, 小鸡, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-AKT Interacting Protein (AKTIP) (AA 262-288), (C-Term) antibodyAKTIP 适用: 人 WB 宿主: 兔 Polyclonal RB38675 unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 292 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
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: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
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- AKTIP (AKT Interacting Protein (AKTIP))
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别名
- AKTIP
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背景
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AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Alias Symbols: FT1, FTS
Protein Interaction Partner: HOOK1, HOOK2, HOOK3, FAM160A2, VPS16, VPS18, VPS41, TRIM23, TRIM41, MARCH5, DZIP3, KIAA1377, EXOC7, POLA2, GTF3C1, UTP14A, C10orf2, PDPK1, ASS1, CTBP2, IMMT, RPA1, AKT1, TIMM50, PDS5A, IARS, HDLBP, DCTN1,
Protein Size: 292 -
分子量
- 33 kDa
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基因ID
- 64400
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NCBI登录号
- NM_001012398, NP_001012398
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UniProt
- Q9H8T0
抗原
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