BLMH 抗体 (Middle Region)
Quick Overview for BLMH 抗体 (Middle Region) (ABIN2786515)
抗原
See all BLMH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- EYLSNMVGGR KTLYNNQPID FLKKMVAASI KDGEAVWFGC DVGKHFNSKL
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预测反应
- Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
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产品特性
- This is a rabbit polyclonal antibody against BLMH. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human BLMH
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anti-Bleomycin Hydrolase (BLMH) (AA 356-454) antibody
BLMH 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Bleomycin Hydrolase (BLMH) (AA 356-454) antibodyBLMH 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A2 unconjugated
anti-Bleomycin Hydrolase (BLMH) (AA 212-242) antibodyBLMH 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bleomycin Hydrolase (BLMH) (AA 1-300) antibodyBLMH 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bleomycin Hydrolase (BLMH) (AA 1-300) antibodyBLMH 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Bleomycin Hydrolase (BLMH) (AA 30-165) antibodyBLMH 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 6# unconjugated
anti-Bleomycin Hydrolase (BLMH) (AA 1-455) antibodyBLMH 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Bleomycin Hydrolase (BLMH) (AA 287-336) antibodyBLMH 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 斑马鱼, Pig, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Bleomycin Hydrolase (BLMH) (AA 60-268) antibodyBLMH 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bleomycin Hydrolase (BLMH) antibodyBLMH 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 455 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- BLMH (Bleomycin Hydrolase (BLMH))
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别名
- BLMH
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背景
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The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution, however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BH, BMH
Protein Interaction Partner: NUDT12, WDYHV1, BLMH, UBC, ZBTB1, SH3GLB2, LZTFL1, GORASP2, PES1, GTF2A1, AP1M2, CYP2C8, RNF32, ECSIT, MAST1, COPS5, CUL4B, SUMO2, PDPK1, Fam134a, USP53, KBTBD7, RPL11, UBE2I, TRIO, RPL29, APP,
Protein Size: 455 -
分子量
- 52 kDa
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基因ID
- 642
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NCBI登录号
- NM_000386, NP_000377
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UniProt
- Q13867
抗原
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