NPHP1 抗体 (Middle Region)
Quick Overview for NPHP1 抗体 (Middle Region) (ABIN2786505)
抗原
See all NPHP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- GILFELGISY IRNSTGERGE LSCGWVFLKL FDASGVPIPA KTYELFLNGG
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
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产品特性
- This is a rabbit polyclonal antibody against NPHP1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human NPHP1
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anti-Nephronophthisis 1 (Juvenile) (NPHP1) (AA 345-614) antibody
NPHP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nephronophthisis 1 (Juvenile) (NPHP1) (AA 1-121) antibodyNPHP1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Nephronophthisis 1 (Juvenile) (NPHP1) (AA 1-109) antibodyNPHP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nephronophthisis 1 (Juvenile) (NPHP1) antibodyNPHP1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nephronophthisis 1 (Juvenile) (NPHP1) antibodyNPHP1 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nephronophthisis 1 (Juvenile) (NPHP1) antibodyNPHP1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Nephronophthisis 1 (Juvenile) (NPHP1) antibody (FITC)NPHP1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal FITC
anti-Nephronophthisis 1 (Juvenile) (NPHP1) (AA 467-516) antibodyNPHP1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig, 兔, Bat, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Nephronophthisis 1 (Juvenile) (NPHP1) (AA 1-109) antibodyNPHP1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nephronophthisis 1 (Juvenile) (NPHP1) (AA 1-121) antibodyNPHP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 733 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- NPHP1 (Nephronophthisis 1 (Juvenile) (NPHP1))
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别名
- NPHP1
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背景
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Together with Cas NPHP1 may play a role in the control of epithelial cell polarity. NPHP1 seems to help to recruit protein tyrosine kinase 2 beta (PTK2B) to cell matrix adhesions, thereby initiating phosphorylation of PTK2B and PTK2B-dependent signaling.This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neonatal breathing abnormalities, sometimes including retinal dystrophy and renal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: JBTS4, NPH1, SLSN1
Protein Interaction Partner: MED28, CEP164, ADAM15, UBQLN4, TNK2, ARHGAP32, BCAR1, KHDRBS1, UBC, NPHP1, INVS, NPHP3, NPHP4, PAK2, FLNB, PTK2B, FLNA, TUBB, FLNC, TNS1,
Protein Size: 733 -
分子量
- 83 kDa
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基因ID
- 4867
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NCBI登录号
- NM_000272, NP_000263
抗原
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