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PRAME 抗体 (N-Term)

PRAME 适用: 人, 小鼠, 大鼠, Cow, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2786466
发货至: 中国
  • 抗原 See all PRAME 抗体
    PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
    抗原表位
    • 16
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 43
    • 19
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 马, 兔
    宿主
    • 41
    • 2
    克隆类型
    • 43
    多克隆
    标记
    • 22
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRAME antibody is un-conjugated
    应用范围
    • 21
    • 16
    • 13
    • 13
    • 9
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    序列
    AMVQAWPFTC LPLGVLMKGQ HLHLETFKAV LDGLDVLLAQ EVRPRRWKLQ
    预测反应
    Cow: 92%, Horse: 79%, Human: 100%, Mouse: 92%, Rabbit: 79%, Rat: 92%
    产品特性
    This is a rabbit polyclonal antibody against PRAME. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human PRAME
    Top Product
    Discover our top product PRAME Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 509 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Sakakura, Kubo, Ako, Ikeda, Funayama, Hirahara, Sugawara, Yasu, Kawakami, Momomura: "Determinants of in-hospital death and rupture in patients with a Stanford B aortic dissection." in: Circulation journal : official journal of the Japanese Circulation Society, Vol. 71, Issue 10, pp. 1521-4, (2007) (PubMed).

  • 抗原
    PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
    别名
    PRAME (PRAME 产品)
    别名
    PRAME antibody, CT130 antibody, MAPE antibody, OIP-4 antibody, OIP4 antibody, 4930534P07Rik antibody, preferentially expressed antigen in melanoma antibody, PRAME antibody, Prame antibody
    背景
    PRAME functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. PRAME prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
    Alias Symbols: MAPE, OIP4, CT130
    Protein Interaction Partner: PRAME, RBX1, CUL2, TCEB2, TCEB1, ZNF408, FBXL12, XRN2, HIST4H4, HIST2H2BE, HIST2H2AC, HIST3H3, UBC, RARA, TP53RK, OSGEP, TPRKB, KDM1A, BAG2, LAGE3, UBL4A, SNRPB, RPS13, RPL22, RPL10, RFC4, PSMC4, HNRNPM, HNRNPH1, HNRNPF, HNRNPC, NEDD8, STK19,
    Protein Size: 509
    分子量
    56 kDa
    基因ID
    23532
    NCBI登录号
    NM_006115, NP_006106
    UniProt
    P78395
    途径
    Retinoic Acid Receptor Signaling Pathway, Nuclear Hormone Receptor Binding
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