PRAME 抗体 (N-Term)
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北京 101111
Quick Overview for PRAME 抗体 (N-Term) (ABIN2786465)
抗原
See all PRAME 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- PRAME Antibody - N-terminal region
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序列
- MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR
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预测反应
- Cow: 86%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 86%, Rat: 85%
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产品特性
- This is a rabbit polyclonal antibody against PRAME. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human PRAME
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anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 416-502) antibody
PRAME 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 151-250) antibodyPRAME 适用: 人 FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 1-509) antibodyPRAME 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 476-502), (C-Term) antibodyPRAME 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18763 unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 1-509) antibodyPRAME 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (C-Term) antibodyPRAME 适用: 人, 小鼠 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) antibodyPRAME 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB4420 unconjugated Recombinant Antibody
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 1-509) antibodyPRAME 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 71-120) antibodyPRAME 适用: 人, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (N-Term) antibodyPRAME 适用: 人, 大鼠, Cow, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP55981-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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: "A novel testis-specific protein, PRAMEY, is involved in spermatogenesis in cattle." in: Reproduction (Cambridge, England), Vol. 153, Issue 6, pp. 847-863, (2017) (PubMed).
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- PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
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别名
- PRAME
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背景
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Background Information: PRAME functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. PRAME prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Gene Name: Preferentially expressed antigen in melanoma
Alternative Symbols: MAPE, OIP4, CT130, OIP-4
Protein Name: Melanoma antigen preferentially expressed in tumors
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分子量
- 56kDa
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基因ID
- 23532
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NCBI登录号
- NP_006106
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UniProt
- P78395
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途径
- Retinoic Acid Receptor Signaling Pathway, Nuclear Hormone Receptor Binding
抗原
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