LDLRAP1 抗体 (N-Term)
Quick Overview for LDLRAP1 抗体 (N-Term) (ABIN2786138)
抗原
See all LDLRAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- WTDTRETLLE GMLFSLKYLG MTLVEQPKGE ELSAAAIKRI VATAKASGKK
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%, Zebrafish: 93%
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产品特性
- This is a rabbit polyclonal antibody against LDLRAP1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human LDLRAP1
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anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 1-263) antibody
LDLRAP1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4G4-D5 unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 1-308) antibodyLDLRAP1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 1-264) antibodyLDLRAP1 适用: 人 WB, IHC, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4G4-D5 unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) antibodyLDLRAP1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (N-Term) antibodyVerified LDLRAP1 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 59-308) antibodyLDLRAP1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) antibodyLDLRAP1 适用: 人, 犬 WB 宿主: 小鼠 Monoclonal 7A5 unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 59-308) antibodyLDLRAP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 35-84) antibodyLDLRAP1 适用: 人, 犬, Cow, 兔, 马, Pig, 猴, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) (AA 277-306), (C-Term) antibodyLDLRAP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB13027 unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 308 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))
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别名
- LDLRAP1
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背景
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LDLRAP1 is an adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. LDLRAP1 may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. LDLRAP1 may also be involved in the internalization of other LDLR family members. LDLRAP1 binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ARH, ARH1, ARH2, DKFZp586D0624, FHCB1, FHCB2, MGC34705
Protein Interaction Partner: OBFC1, AP2B1, UBC, KLC1, LDLR, LRP2, CLTC, TFAP2A, APP,
Protein Size: 308 -
分子量
- 34 kDa
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基因ID
- 26119
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NCBI登录号
- NM_015627, NP_056442
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UniProt
- Q5SW96
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途径
- Lipid Metabolism
抗原
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