LYN 抗体 (N-Term)
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- 抗原 See all LYN 抗体
- LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠, Cow, 绵羊, Pig, 犬, 豚鼠, 马, 兔
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LYN antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- DPTSNKQQRP VPESQLLPGQ RFQTKDPEEQ GDIVVALYPY DGIHPDDLSF
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 93%, Sheep: 100%
- 产品特性
- This is a rabbit polyclonal antibody against LYN. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human LYN
- Top Product
- Discover our top product LYN Primary Antibody
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anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (pTyr507) antibody
LYN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (C-Term) antibodyLYN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (Center) antibodyLYN 适用: 人 WB, IP, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 32-62) antibodyLYN 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 229-263) antibodyLYN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 470-501) antibodyLYN 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (pTyr508) antibodyLYN 适用: 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 犬, 豚鼠 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (pTyr397) antibodyLYN 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 229-263) antibodyLYN 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB50588 unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (Ser780) antibodyLYN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 512 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
- 别名
- LYN (LYN 产品)
- 别名
- JTK8 antibody, p53Lyn antibody, p56Lyn antibody, lyn antibody, LYN antibody, AA407514 antibody, Hck-2 antibody, jtk8 antibody, lyn-A antibody, CH73-38P6.3 antibody, zgc:92124 antibody, LYN proto-oncogene, Src family tyrosine kinase antibody, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog antibody, tyrosine-protein kinase Lyn antibody, LYN proto-oncogene, Src family tyrosine kinase L homeolog antibody, LYN antibody, lyn antibody, Lyn antibody, LOC100593961 antibody, lyn.L antibody
- 背景
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LYN down regulates expression of stem cell growth factor receptor (KIT).LYN acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation.LYN acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents.LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.
Alias Symbols: FLJ26625, JTK8, p53Lyn, p56Lyn
Protein Interaction Partner: UBC, IKBKG, TRIM28, EGFR, RGS16, TNF, IL1B, ANGPT2, DKFZP434K028, CNOT10, TGDS, CBX6, FBXO28, ZNF423, RASSF8, FRS2, HBS1L, TUBB4A, SH2D3C, RIMS2, DDX21, KYNU, TNFSF12, PIK3R3, YEATS4, ZNF189, UGP2, HSP90B1, TADA2A, SLC12A4, RDX, PRKCB, SCIMP, LNP1, RNF180
Protein Size: 512 - 分子量
- 58 kDa
- 基因ID
- 4067
- NCBI登录号
- NM_002350, NP_002341
- UniProt
- P07948
- 途径
- Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling
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