NARF 抗体 (Middle Region)
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Quick Overview for NARF 抗体 (Middle Region) (ABIN2785739)
抗原
See all NARF 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- FRNIQNMILK LKKGKFPFHF VEVLACAGGC LNGRGQAQTP DGHADKALLR
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预测反应
- Cow: 92%, Dog: 86%, Guinea Pig: 92%, Horse: 86%, Human: 100%, Mouse: 92%, Rabbit: 79%, Rat: 92%
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产品特性
- This is a rabbit polyclonal antibody against NARF. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human NARF
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anti-Nuclear Prelamin A Recognition Factor (NARF) antibody
NARF 适用: 小鼠, 大鼠 IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Prelamin A Recognition Factor (NARF) (AA 10-41) antibodyNARF 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Prelamin A Recognition Factor (NARF) antibodyNARF 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Prelamin A Recognition Factor (NARF) (C-Term) antibodyNARF 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Prelamin A Recognition Factor (NARF) (AA 395-444) antibodyNARF 适用: 人, 马, 兔, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Prelamin A Recognition Factor (NARF) (AA 323-372) antibodyNARF 适用: 人, 马, 兔, Cow, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Prelamin A Recognition Factor (NARF) (AA 1-100) antibodyNARF 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7D9 unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 502 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- NARF (Nuclear Prelamin A Recognition Factor (NARF))
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别名
- NARF
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背景
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Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. NARF binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. NARF is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases.Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.
Alias Symbols: DKFZp434G0420, FLJ10067, IOP2
Protein Interaction Partner: UBC, LEF1, STAT5A, SHFM1, MMS19, CBX5, APP, LMNA,
Protein Size: 502 -
分子量
- 55 kDa
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基因ID
- 26502
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NCBI登录号
- NM_031968, NP_114174
抗原
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