GAD 抗体 (N-Term)
Quick Overview for GAD 抗体 (N-Term) (ABIN2785666)
抗原
See all GAD (GAD1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against GAD1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human GAD1
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 594 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- GAD (GAD1) (Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))
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别名
- GAD1
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背景
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This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Alias Symbols: FLJ45882, GAD, SCP, CPSQ1
Protein Interaction Partner: CMTM5, AGTRAP, HAAO, STK3, GAD2, PPP2CA, PRKCE, PPP2CB, PRKACA,
Protein Size: 594 -
分子量
- 67 kDa
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基因ID
- 2571
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NCBI登录号
- NM_000817, NP_000808
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UniProt
- Q99259
抗原
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