GCAP1 抗体 (N-Term)
Our Local Distributor
北京 101111
Quick Overview for GCAP1 抗体 (N-Term) (ABIN2785648)
抗原
See all GCAP1 (GUCA1A) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- N-Term
-
原理
- GUCA1A Antibody - N-terminal region
-
序列
- LYEFRQFFGL KNLSPSASQY VEQMFETFDF NKDGYIDFME YVAALSLVLK
-
预测反应
- Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%
-
产品特性
- This is a rabbit polyclonal antibody against GUCA1A. It was validated on Western Blot using a cell lysate as a positive control.
-
纯化方法
- Affinity Purified
-
免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human GUCA1A
-
-
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 1-93) antibody
GUCA1A 适用: 人 WB, RNAi 宿主: 小鼠 Monoclonal 2F7 unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) antibodyGUCA1A 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 36-85) antibodyGUCA1A 适用: 人, 小鼠, 大鼠, 犬, 马, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
说明
-
We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54309-100UG
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.5 mg/mL
-
缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- prevent freeze-thaw cycles
-
储存条件
- 4 °C,-20 °C
-
储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
-
-
- GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
-
别名
- GUCA1A
-
背景
-
Background Information: GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3), a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations, causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.
Gene Name: Guanylate cyclase activator 1A (retina)
Alternative Symbols: COD3, GCAP, GUCA, GCAP1, GUCA1, CORD14, C6orf131
Protein Name: Guanylyl cyclase-activating protein 1
-
分子量
- 23kDa
-
基因ID
- 2978
-
NCBI登录号
- NP_000400
-
UniProt
- P43080
-
途径
- Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
抗原
-
