PIAS2 抗体 (N-Term)
-
- 抗原 See all PIAS2 抗体
- PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
-
抗原表位
- N-Term
-
适用
- 人, 小鼠, 大鼠, 犬, Cow, 兔, 马, 豚鼠, 斑马鱼
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This PIAS2 antibody is un-conjugated
-
应用范围
- Western Blotting (WB)
- 序列
- PAVQIKIREL YRRRYPRTLE GLCDLSTIKS SVFSLDGSSS PVEPDLPVAG
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 83%
- 产品特性
- This is a rabbit polyclonal antibody against Pias2. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- Top Product
- Discover our top product PIAS2 Primary Antibody
-
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 385-473) antibody
PIAS2 适用: 人 WB, ELISA, IF, PLA, RNAi 宿主: 小鼠 Monoclonal 1F7 unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) antibodyPIAS2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (C-Term) antibodyPIAS2 适用: 人, 小鼠, 犬, Cow, 兔, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 109-140), (N-Term) antibodyPIAS2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0678 unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (N-Term) antibodyPIAS2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (C-Term) antibodyPIAS2 适用: 人, 小鼠, 犬, Cow, 兔, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (N-Term) antibodyPIAS2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
-
Antigen size: 580 AA
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- 抗原
- PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
- 别名
- Pias2 (PIAS2 产品)
- 别名
- MGC83751 antibody, piasx antibody, wu:fi05f09 antibody, PIAS2 antibody, 6330408K17Rik antibody, AI462206 antibody, ARIP3 antibody, AU018068 antibody, Dib antibody, Miz1 antibody, PIASxalpha antibody, PIASxb antibody, PIASxbeta antibody, SIZ2 antibody, DIP antibody, MIZ antibody, MIZ1 antibody, PIASX antibody, PIASX-ALPHA antibody, PIASX-BETA antibody, ZMIZ4 antibody, protein inhibitor of activated STAT 2 L homeolog antibody, protein inhibitor of activated STAT 2 antibody, protein inhibitor of activated STAT, 2 antibody, pias2.L antibody, PIAS2 antibody, pias2 antibody, Pias2 antibody
- 背景
-
Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.Pias2 plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing.Pias2 binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIASx-beta, but not isoform PIASx-alpha, promotes MDM2 sumoylation. Isoform PIASx-alpha promotes PARK7 sumoylation. Isoform PIASx-beta promotes NCOA2 sumoylation more efficiently than isoform PIASx-alpha
Alias Symbols: 6330408K17Rik, AI462206, ARIP3, AU018068, Dib, Miz1, PIASxalpha, PIASxb, PIASxbeta, SIZ2
Protein Interaction Partner: Pparg, Egr2, Plagl2, Trim32, Trp53, DHX9, Nfkb1, Gtf2i, GTF2IRD1, HDAC3,
Protein Size: 580 - 分子量
- 63 kDa
- 基因ID
- 17344
- NCBI登录号
- NM_001164167, NP_001157639
- 途径
- JAK/STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
-
