PACRG 抗体 (Middle Region)
(2 references)Quick Overview for PACRG 抗体 (Middle Region) (ABIN2785168)
抗原
See all PACRG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- GAIMARCNLD HLGSSDPPTS ASQVAEIIVN SGDGIDYSQQ KRENIGDLIQ
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预测反应
- Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
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产品特性
- This is a rabbit polyclonal antibody against PACRG. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human PACRG
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anti-PARK2 Co-Regulated (PACRG) (AA 1-257) antibody
PACRG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-PARK2 Co-Regulated (PACRG) (AA 216-265) antibodyPACRG 适用: 人, 小鼠, 大鼠, 小鸡, 斑马鱼, Cow, 马, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-PARK2 Co-Regulated (PACRG) (AA 150-250) antibodyPACRG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 296 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases." in: Neurobiology of disease, Vol. 27, Issue 2, pp. 238-47, (2007) (PubMed).
: "Modelling 2,4-dichlorophenol bioavailability and bioaccumulation by the freshwater fingernail clam Sphaerium corneum using artificial particles and humic acids." in: Environmental pollution (Barking, Essex : 1987), Vol. 145, Issue 1, pp. 238-44, (2006) (PubMed).
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: "Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases." in: Neurobiology of disease, Vol. 27, Issue 2, pp. 238-47, (2007) (PubMed).
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- PACRG (PARK2 Co-Regulated (PACRG))
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别名
- PACRG
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背景
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PACRG is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death.This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: FLJ32724, GLUP, HAK005771, PARK2CRG, RP3-495O10.2
Protein Interaction Partner: UBC, TUBB, HOPX, CCT5, CCT8, CCT2, CCT4, CCT7, STUB1, TUBA1A, VCP, CCT3, TCP1, PARK2, HSP90AA1, HSPA4, DNAJA1, GPR37, CCT6A, APP,
Protein Size: 296 -
分子量
- 33 kDa
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基因ID
- 135138
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NCBI登录号
- NM_152410, NP_689623
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UniProt
- Q96M98
抗原
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