EGLN3 抗体 (C-Term)
Quick Overview for EGLN3 抗体 (C-Term) (ABIN2784911)
抗原
See all EGLN3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
序列
- FWSDRRNPHE VQPSYATRYA MTVWYFDAEE RAEAKKKFRN LTRKTESALT
-
预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 77%, Zebrafish: 75%
-
产品特性
- This is a rabbit polyclonal antibody against EGLN3. It was validated on Western Blot using a cell lysate as a positive control.
-
纯化方法
- Affinity Purified
-
免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human EGLN3
-
-
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-120) antibody
EGLN3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-239) antibodyEGLN3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-120) antibodyEGLN3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 2-239) antibodyEGLN3 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (C-Term) antibodyEGLN3 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 猴, 豚鼠, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 94-193) antibodyEGLN3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3C5 unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (Internal Region) antibodyVerified EGLN3 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) antibodyEGLN3 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-239) antibodyEGLN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 50-100) antibodyEGLN3 适用: 人, 大鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
-
说明
-
Antigen size: 239 AA
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- Lot specific
-
缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
-
别名
- EGLN3
-
背景
-
EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
Alias Symbols: FLJ21620, HIFPH3, MGC125998, MGC125999, PHD3
Protein Interaction Partner: FOXJ2, SERTAD1, NCAPH2, EFHC2, ABI2, SIAH2, REL, HIF1A, TTC23L, SQSTM1, HEXIM1, IKBKG, IKBKB, CHUK, MAPK7, MAPK6, MAPK1, PKM, EPAS1, UBD, MAGEA11, UBC, ATF4, WTIP, AJUBA, LIMD1, SPRY2, ADRB2, PRPF19, Myog, EGLN3, EGLN2, EGLN1, OS9, HIF3A, WDR83,
Protein Size: 239 -
分子量
- 27 kDa
-
基因ID
- 112399
-
NCBI登录号
- NM_022073, NP_071356
-
UniProt
- Q9H6Z9
-
途径
- Positive Regulation of Endopeptidase Activity
抗原
-
