SENP6 抗体 (C-Term)
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北京 101111
Quick Overview for SENP6 抗体 (C-Term) (ABIN2784244)
抗原
See all SENP6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Senp6 Antibody - C-terminal region
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序列
- LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS
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预测反应
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against Senp6. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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anti-SUMO1/sentrin Specific Protease 6 (SENP6) (AA 1-110) antibody
SENP6 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 4B7 unconjugated
anti-SUMO1/sentrin Specific Protease 6 (SENP6) (AA 1081-1112), (C-Term) antibodySENP6 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0664 unconjugated
anti-SUMO1/sentrin Specific Protease 6 (SENP6) (Internal Region) antibodyVerified SENP6 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-SUMO1/sentrin Specific Protease 6 (SENP6) antibodySENP6 适用: 人 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term) antibodySENP6 适用: 人, Cow, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term) antibodySENP6 适用: 人, Cow, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-SUMO1/sentrin Specific Protease 6 (SENP6) (Internal Region) antibodySENP6 适用: 人, 小鼠 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-SUMO1/sentrin Specific Protease 6 (SENP6) (AA 1-270) antibodySENP6 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term) antibodySENP6 适用: 人, 小鼠, 大鼠 IHC, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50599-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
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别名
- Senp6
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背景
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Background Information: Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Gene Name: SUMO/sentrin specific peptidase 6
Alternative Symbols: Susp1, mKIAA0797, 2810017C20Rik, E130319N12Rik
Protein Name: Sentrin-specific protease 6
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分子量
- 127kDa
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基因ID
- 215351
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NCBI登录号
- NP_666115
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UniProt
- Q6P7W0
抗原
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