GADD45B 抗体 (Middle Region)
(5 references)Quick Overview for GADD45B 抗体 (Middle Region) (ABIN2783334)
抗原
See all GADD45B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against GADD45B. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human GADD45B
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anti-Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) (AA 81-160) antibody
GADD45B 适用: 人, 小鼠 ELISA, WB, FACS, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) (AA 1-160) antibodyGADD45B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) (AA 1-160) antibodyGADD45B 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) (C-Term) antibodyGADD45B 适用: 人, 小鼠, 大鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) (Middle Region) antibodyGADD45B 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 160 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "BDNF rs6265 methylation and genotype interact on risk for schizophrenia. ..." in: Epigenetics, Vol. 11, Issue 1, pp. 11-23, (2016) (PubMed).
: "Role of Growth Arrest and DNA Damage-Inducible, Beta in Alcohol-Drinking Behaviors." in: Alcoholism, clinical and experimental research, Vol. 40, Issue 2, pp. 263-72, (2016) (PubMed).
: "Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain." in: Molecular pharmacology, Vol. 80, Issue 1, pp. 174-82, (2011) (PubMed).
: "Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 37, Issue 2, pp. 531-42, (2011) (PubMed).
: "Gadd45 beta forms a homodimeric complex that binds tightly to MKK7." in: Journal of molecular biology, Vol. 378, Issue 1, pp. 97-111, (2008) (PubMed).
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: "BDNF rs6265 methylation and genotype interact on risk for schizophrenia. ..." in: Epigenetics, Vol. 11, Issue 1, pp. 11-23, (2016) (PubMed).
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- GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))
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别名
- GADD45B
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背景
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The function of GADD45B is involved in the regulation of growth and apoptosis.This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DKFZP566B133, GADD45BETA, MYD118
Protein Interaction Partner: UBD, UBC, MAP3K4, GADD45GIP1, GADD45G, MAP2K7, MAP3K5, PPARG, PPARD, PCNA, PPARA, ESR1, CCNB1, CDK1, CDKN1A, GADD45A, EGR1,
Protein Size: 160 -
分子量
- 18 kDa
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基因ID
- 4616
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NCBI登录号
- NM_015675, NP_056490
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UniProt
- O75293
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途径
- Cell Division Cycle
抗原
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