FTO 抗体 (N-Term)
Quick Overview for FTO 抗体 (N-Term) (ABIN2782980)
抗原
See all FTO 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV
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预测反应
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Yeast: 90%
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产品特性
- This is a rabbit polyclonal antibody against Fto. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide corresponding to a region of Mouse
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 502 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- FTO (Fat Mass and Obesity-Associated (FTO))
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别名
- Fto
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背景
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Fto is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Fto has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Fto has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Fto has no activity towards 1-methylguanine and no detectable activity towards double-stranded DNA. Fto requires molecular oxygen, alpha-ketoglutarate and iron. Fto contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Fto contributes to the regulation of body size and body fat accumulation.
Alias Symbols: AW743446, mKIAA1752
Protein Interaction Partner: Eed,
Protein Size: 502 -
分子量
- 58 kDa
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基因ID
- 26383
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NCBI登录号
- NM_011936, NP_036066
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UniProt
- Q8BGW1
抗原
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