Calsyntenin 1 抗体 (N-Term)
Quick Overview for Calsyntenin 1 抗体 (N-Term) (ABIN2781932)
抗原
See all Calsyntenin 1 (CLSTN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- KPWLEPTYHG IVTENDNTVL LDPPLIALDK DAPLRFAESF EVTVTKEGEI
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预测反应
- Cow: 82%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
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产品特性
- This is a rabbit polyclonal antibody against CLSTN1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human CLSTN1
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anti-Calsyntenin 1 (CLSTN1) (AA 35-84) antibody
CLSTN1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 斑马鱼, Bat, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calsyntenin 1 (CLSTN1) (AA 1-971) antibodyCLSTN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Calsyntenin 1 (CLSTN1) (C-Term) antibodyCLSTN1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calsyntenin 1 (CLSTN1) (AA 29-350) antibodyCLSTN1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Calsyntenin 1 (CLSTN1) antibodyKD Validated CLSTN1 适用: 人, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 981 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Calsyntenin 1 (CLSTN1)
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别名
- CLSTN1
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背景
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CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment,CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
Alias Symbols: CSTN1, FLJ32258, KIAA0911, PIK3CD, XB31alpha, alcalpha1, alcalpha2, CDHR12, ALC-ALPHA
Protein Interaction Partner: MDM2, BAHCC1, SETDB1, SLK, TRIP12, MCM3AP, UBC, KLC2, CLSTN1, TOPBP1, APBA2, APBB1, KIF2A, KLC1, PRNP, COL17A1, PSEN1, APP,
Protein Size: 981 -
分子量
- 110 kDa
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基因ID
- 22883
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NCBI登录号
- NM_001009566, NP_001009566
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UniProt
- O94985
抗原
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