TRIM11 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for TRIM11 抗体 (C-Term) (ABIN2781254)
抗原
See all TRIM11 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
序列
- GSFYNSNEPA FSPLRDPPKR VGIFLDYEAG HLSFYSATDG SLLFIFPETL
-
预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%
-
产品特性
- This is a rabbit polyclonal antibody against Trim11. It was validated on Western Blot.
-
纯化方法
- Affinity Purified
-
免疫原
- The immunogen is a synthetic peptide corresponding to a region of Mouse
-
-
anti-Tripartite Motif Containing 11 (TRIM11) (AA 267-468) antibody
TRIM11 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 11 (TRIM11) (C-Term) antibodyVerified TRIM11 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Tripartite Motif Containing 11 (TRIM11) (AA 249-263) antibodyVerified TRIM11 适用: 人 ELISA, WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Tripartite Motif Containing 11 (TRIM11) (AA 383-432) antibodyTRIM11 适用: 人, 小鼠, 大鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 11 (TRIM11) (AA 300-329), (C-Term) antibodyTRIM11 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33239 unconjugated
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
-
说明
-
Antigen size: 467 AA
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- Lot specific
-
缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
- TRIM11 (Tripartite Motif Containing 11 (TRIM11))
-
别名
- Trim11
-
背景
-
Trim11 is an E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. It may also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. It may contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. It mediates MED15 ubiquitination leading to proteasomal degradation. Trim11 may contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. Trim11 may regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
Alias Symbols: -
Protein Interaction Partner: TBK1, Pax6, Phox2b,
Protein Size: 467 -
分子量
- 52 kDa
-
基因ID
- 94091
-
NCBI登录号
- NM_053168, NP_444398
-
UniProt
- Q99PQ2
抗原
-
