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TRIM32 抗体 (N-Term)

This anti-TRIM32 antibody is a 兔 多克隆 antibody detecting TRIM32 in WB. Suitable for 人, 小鼠, 大鼠, 犬, Cow, 马, 兔 和 豚鼠. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN2780865
发货至: 中国

Quick Overview for TRIM32 抗体 (N-Term) (ABIN2780865)

抗原

See all TRIM32 抗体
TRIM32 (Tripartite Motif Containing 32 (TRIM32))

适用

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人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠

宿主

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克隆类型

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多克隆

标记

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This TRIM32 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    N-Term

    序列

    MAAAAASHLN LDALREVLEC PICMESFTEE QLRPKLLHCG HTICRQCLEK

    预测反应

    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 93%, Mouse: 93%, Rabbit: 93%, Rat: 93%

    产品特性

    This is a rabbit polyclonal antibody against TRIM32. It was validated on Western Blot using a cell lysate as a positive control.

    纯化方法

    Protein A purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N terminal region of human TRIM32
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 653 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Streich, Ronchi, Connick, Haas: "Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism." in: The Journal of biological chemistry, Vol. 288, Issue 12, pp. 8209-21, (2013) (PubMed).

    Kudryashova, Wu, Havton, Spencer: "Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component." in: Human molecular genetics, Vol. 18, Issue 7, pp. 1353-67, (2009) (PubMed).

  • 抗原

    TRIM32 (Tripartite Motif Containing 32 (TRIM32))

    别名

    TRIM32

    背景

    TRIM32 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM32 localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.
    Alias Symbols: HT2A, BBS11, TATIP, LGMD2H
    Protein Interaction Partner: PTPN11, PDE9A, PTCD2, CLIP4, KCTD9, UBQLN1, TRIM32, RABAC1, ABI2, SCGB1A1, UBE2E1, UBE2D1, UBC, TP53, SDCBP, UBE2U, SYT6, MYCN, CEP250, CUL3, GPRASP2, GLIS2, YWHAB, TP73, UBE2D3, UBE2D2, HSP90AA1, SFN, YWHAQ, YWHAZ, YWHAH, YWHAG, YWHAE, NOTCH1, UBD, TOP1,
    Protein Size: 653

    分子量

    72 kDa

    基因ID

    22954

    NCBI登录号

    NM_012210, NP_036342

    UniProt

    Q13049

    途径

    Negative Regulation of intrinsic apoptotic Signaling
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