RNF14 抗体 (C-Term)
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北京 101111
Quick Overview for RNF14 抗体 (C-Term) (ABIN2780586)
抗原
See all RNF14 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- RNF14 Antibody - C-terminal region
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序列
- CMQYFCWICM GSLSRANPYK HFNDPGSPCF NRLFYAVDVD DDIWEDEVED
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预测反应
- Cow: 79%, Dog: 79%, Human: 100%, Rabbit: 79%, Rat: 79%
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产品特性
- This is a rabbit polyclonal antibody against RNF14. It was validated on Western Blot and immunohistochemistry.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human RNF14
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38448-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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: "Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice." in: Cell, Vol. 119, Issue 1, pp. 121-35, (2004) (PubMed).
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- RNF14 (Ring Finger Protein 14 (RNF14))
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别名
- RNF14
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背景
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Background Information: RNF14 contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins.The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.
Gene Name: Ring finger protein 14
Alternative Symbols: ARA54, HFB30, TRIAD2, HRIHFB2038
Protein Name: E3 ubiquitin-protein ligase RNF14
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分子量
- 52kDa
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基因ID
- 9604
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NCBI登录号
- NP_899648
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UniProt
- Q9UBS8
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
抗原
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