SUPT4H 抗体 (Middle Region)
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- 抗原 See all SUPT4H (SUPT4H1) 抗体
- SUPT4H (SUPT4H1) (Suppressor of Ty 4 Homolog 1 (SUPT4H1))
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抗原表位
- Middle Region
- 适用
- 人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 马, 斑马鱼, 犬
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SUPT4H antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- NCDAYLQMKG NREMVYDCTS SSFDGIIAMM SPEDSWVSKW QRVSNFKPGV
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
- 产品特性
- This is a rabbit polyclonal antibody against SUPT4H1. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human SUPT4H1
- Top Product
- Discover our top product SUPT4H1 Primary Antibody
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anti-Suppressor of Ty 4 Homolog 1 (SUPT4H1) (AA 18-117) antibody
SUPT4H1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3G4 unconjugated
anti-Suppressor of Ty 4 Homolog 1 (SUPT4H1) (AA 1-117) antibodySUPT4H1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 4 Homolog 1 (SUPT4H1) (C-Term) antibodySUPT4H1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 4 Homolog 1 (SUPT4H1) (AA 18-117) antibodySUPT4H1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Suppressor of Ty 4 Homolog 1 (SUPT4H1) (AA 57-106) antibodySUPT4H1 适用: 人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Ty 4 Homolog 1 (SUPT4H1) (C-Term) antibodySUPT4H1 适用: 人, 小鼠, 大鼠, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 117 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- SUPT4H (SUPT4H1) (Suppressor of Ty 4 Homolog 1 (SUPT4H1))
- 别名
- SUPT4H1 (SUPT4H1 产品)
- 别名
- SPT4 antibody, SPT4H antibody, SUPT4H antibody, Supt4h2 antibody, AL022777 antibody, Supt4h antibody, Supt4h1 antibody, Supt4h1a antibody, 142904_at antibody, CG12372 antibody, DSIF antibody, Dmel\\CG12372 antibody, Dspt4 antibody, Spt4 antibody, dDSIF antibody, dspt4 antibody, l(2)k05316 antibody, DSIF small subunit antibody, spt4 antibody, zgc:92824 antibody, SPT4 homolog, DSIF elongation factor subunit antibody, suppressor of Ty 4A antibody, Transcription elongation factor SPT4 antibody, CG12372 gene product from transcript CG12372-RA antibody, SPT4 homolog, DSIF elongation factor subunit L homeolog antibody, transcription elongation factor antibody, transcription elongation factor complex subunit Spt4 antibody, SUPT4H1 antibody, Supt4h1 antibody, Supt4a antibody, spt-4 antibody, spt4 antibody, supt4h1.L antibody, CAALFM_C504630WA antibody, supt4h1 antibody
- 背景
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SUPT4H1 is a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
Alias Symbols: SPT4H, SUPT4H, SPT4
Protein Interaction Partner: UBC, tat, SUPT5H, ZMYND8, APP, LRIF1, HMP19, PDLIM1, EWSR1, XRCC5, HTATSF1, ANXA5,
Protein Size: 117 - 分子量
- 13 kDa
- 基因ID
- 6827
- NCBI登录号
- NM_003168, NP_003159
- UniProt
- P63272
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