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E2F3 抗体 (C-Term)

Name: E2F3 抗体 (C-Term)
SKU: ABIN2780388
Availability: OutOfStock

Cited in 3+ publications. This 兔多克隆 anti-E2F3 antibody specifically detects E2F3 in WB. The antibody is reactive with 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马和兔 samples.

WB Suggested Anti-E2F3 Antibody Titration: 0. (E2F3 抗体 (C-Term))

Host: Mouse Target Name: E2F3 Sample Tissue: Mouse Small Intestine Antibody Dilution: 1ug/ml (E2F3 抗体 (C-Term))

Host: Rabbit Target Name: E2F3 Sample Tissue: Human Lung Tumor Antibody Dilution: 1ug/ml (E2F3 抗体 (C-Term))

Host: Rabbit Target Name: E2F3 Sample Tissue: Human Ovary Tumor Antibody Dilution: 1. (E2F3 抗体 (C-Term))

4 images

(3 references)

产品编号 ABIN2780388

发货至: 中国

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中国
北京 101111

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Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for E2F3 抗体 (C-Term) (ABIN2780388)

抗原

See all E2F3 抗体

E2F3

适用

人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔

宿主

兔

克隆类型

多克隆

标记

This E2F3 antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product E2F3 Primary Antibody

抗原表位
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C-Term

序列

LLQQTEDQIP SNLEGPFVNL LPPLLQEDYL LSLGEEEGIS DLFDAYDLEK

特异性

The immunizing peptide used to raise this antibody is 100 % homologous to isoform 2 (334aa, 37 kDa) of human E2F3.

预测反应

Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

产品特性

This is a rabbit polyclonal antibody against E2F3. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the C terminal region of human E2F3
anti-E2F3 (AA 336-425) antibody
适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 5F7 unconjugated

anti-E2F3 (AA 381-465) antibody
适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-E2F3 (C-Term) antibody
适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Bat, Pig, Hamster WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated

anti-E2F3 (acLys168) antibody
适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-E2F3 (AA 200-300) antibody
适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-E2F3 (AA 1-108) antibody
适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-E2F3 (C-Term) antibody
Verified 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-E2F3 (AA 1-133) antibody
适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-E2F3 (AA 1-133) antibody
适用: 人 ELISA 宿主: 小鼠 Monoclonal 3C11 unconjugated

anti-E2F3 (C-Term) antibody
适用: 人, 小鼠, 大鼠, Cow, 犬, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 334 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Giangreco, Vaishnav, Wagner, Finelli, Fleshner, Van der Kwast, Vieth, Nonn: "Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue." in: Cancer prevention research (Philadelphia, Pa.), Vol. 6, Issue 5, pp. 483-94, (2013) (PubMed).

Melcher, Hartmann, Zopf, Herterich, Wilke, Müller, Rosler, Kudlich, Al-Taie, Rosenwald, Katzenberger, Scholtka, Seibold, Rogoll, Scheppach, Scheurlen, Lührs: "LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability." in: Carcinogenesis, Vol. 32, Issue 4, pp. 636-42, (2011) (PubMed).

Naga Prasad, Duan, Gupta, Surampudi, Volinia, Calin, Liu, Kotwal, Moravec, Starling, Perez, Sen, Wu, Plow, Croce, Karnik: "Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27487-99, (2009) (PubMed).
抗原

E2F3

背景

E2F3 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. E2F3 binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.
Alias Symbols: E2F-3
Protein Interaction Partner: RB1, TRIM28, TFDP1, HDAC1, SRA1, RBL1, FZR1, ELAVL1, PCNA, MCM4, HELLS, CCNB1, BCL6, ATAD2, HCFC1, USF1, KMT2D, RYBP, TFDP2, YY1, TFE3, SP1, CCNA2, CDK3, RNF144A, FHL2, WNK1, MGA, TEAD3, SPIB, PKIB, MYBL2, CREBBP, EAPP, JMY, PPP1R13B, TP53BP2, TP53INP1, B
Protein Size: 465

分子量

49 kDa

基因ID

1871

NCBI登录号

NM_001243076

UniProt

Q68DT0