MITF 抗体 (Middle Region)
Quick Overview for MITF 抗体 (Middle Region) (ABIN2780334)
抗原
See all MITF 抗体适用
宿主
克隆类型
标记
应用范围
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                                            抗原表位
- Middle Region
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                                            序列
- MGSKLEDILM DDTLSPVGVT DPLLSSVSPG ASKTSSRRSS MSMEETEHTC
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                                            预测反应
- Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
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                                            产品特性
- This is a rabbit polyclonal antibody against MITF. It was validated on Western Blot using a cell lysate as a positive control.
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                                            纯化方法
- Affinity Purified
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                                            免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human MITF
 
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                                            应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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                                            说明
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                        Antigen size: 419 AA 
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            浓度
- Lot specific
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                                            缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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                                            储存液
- Sodium azide
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                                            注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            注意事项
- Avoid repeated freeze-thaw cycles.
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                                            储存条件
- -20 °C
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                                            储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
 
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    - 
                                            : "BDNF rs6265 methylation and genotype interact on risk for schizophrenia. ..."    in: Epigenetics, Vol. 11, Issue 1, pp. 11-23, (2016)         (PubMed).        
 
 
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                                            : "BDNF rs6265 methylation and genotype interact on risk for schizophrenia. ..."    in: Epigenetics, Vol. 11, Issue 1, pp. 11-23, (2016)         (PubMed).        
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    - MITF (Microphthalmia-Associated Transcription Factor (MITF))
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                                            别名
- MITF
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                                            背景
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                        MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
 Alias Symbols: WS2A, MI, WS2, bHLHe32
 Protein Interaction Partner: EBP, STUB1, HK3, EPAS1, LEF1, APP, HINT1, ELAVL1, CDK2, SUMO2, PSMD14, MARK3, PIAS3, PIAS2, PIAS1, SUMO1, UBE2I, PAX3, OTX2, PAX6, PATZ1, GSK3B, TFEC, EP300, RPS6KA1, TFEB, MAPK14, TFE3, MAPK1, SPI1, FOS, CTNNB1, CDKN1A, RB1,
 Protein Size: 419
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                                            分子量
- 47 kDa
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                                            基因ID
- 4286
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                                            NCBI登录号
- NM_000248, NP_000239
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                                            途径
- Chromatin Binding
 抗原
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