G3BP1 抗体 (N-Term)
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北京 101111
Quick Overview for G3BP1 抗体 (N-Term) (ABIN2780221)
抗原
See all G3BP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- G3BP Antibody - N-terminal region
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序列
- EVFGGFVTEP QEESEEEVEE PEERQQTPEV VPDDSGTFYD QAVVSNDMEE
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against G3BP. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human G3BP
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP37713-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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: "Coxsackievirus counters the host innate immune response by blocking type III interferon expression." in: The Journal of general virology, Vol. 97, Issue 6, pp. 1-12, (2016) (PubMed).
: "Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication." in: Open biology, Vol. 6, Issue 7, (2016) (PubMed).
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- G3BP1 (GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1))
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别名
- G3BP
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背景
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Background Information: G3BP is one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Gene Name: GTPase activating protein (SH3 domain) binding protein 1
Alternative Symbols: G3BP, HDH-VIII
Protein Name: Ras GTPase-activating protein-binding protein 1
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分子量
- 51kDa
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基因ID
- 10146
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NCBI登录号
- NP_005745
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UniProt
- Q13283
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途径
- SARS-CoV-2 Protein Interactome
抗原
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