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AIRE 抗体 (N-Term)

AIRE 适用: 人, 大鼠, 犬, 马, Cow, Pig WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2779776
发货至: 中国
  • 抗原 See all AIRE 抗体
    AIRE (Autoimmune Regulator (AIRE))
    抗原表位
    • 10
    • 9
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 51
    • 23
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    人, 大鼠, 犬, 马, Cow, Pig
    宿主
    • 46
    • 7
    • 1
    克隆类型
    • 53
    多克隆
    标记
    • 38
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AIRE antibody is un-conjugated
    应用范围
    • 39
    • 25
    • 19
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    序列
    DFWRVLFKDY NLERYGRLQP ILDSFPKDVD LSQPRKGRKP PAVPKALVPP
    预测反应
    Cow: 79%, Dog: 92%, Horse: 86%, Human: 100%, Pig: 93%, Rat: 79%
    产品特性
    This is a rabbit polyclonal antibody against AIRE. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Protein A purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE
    Top Product
    Discover our top product AIRE Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 545 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tao, Kupfer, Stewart, Williams-Skipp, Crowell, Patel, Sain, Scheinman: "AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix." in: Molecular immunology, Vol. 43, Issue 4, pp. 335-45, (2005) (PubMed).

  • 抗原
    AIRE (Autoimmune Regulator (AIRE))
    别名
    AIRE (AIRE 产品)
    别名
    AIRE1 antibody, APECED antibody, APS1 antibody, APSI antibody, PGA1 antibody, autoimmune regulator antibody, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) antibody, AaeL_AAEL013794 antibody, CpipJ_CPIJ001208 antibody, CpipJ_CPIJ001209 antibody, AIRE antibody, Aire antibody
    背景
    AIRE is a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
    Alias Symbols: APS1, APSI, PGA1, AIRE1, APECED
    Protein Interaction Partner: TUBB, RAVER1, TUBA1C, TMPRSS13, CCDC87, FAT1, GIGYF2, SRRM2, TUBB4B, EIF4EBP3, UBB, HSP90AB1, HSPA8, HSPA5, HSPA1L, HSPA1A, ATP4A, HIST3H3, HDAC2, HDAC1, DAXX, AIRE, UBAC1, HIST1H3A, HIST2H2BE, HSPA4, SRSF1, SMC1A, XPO1, TOP2A, SSRP1, SNRPD3, SNRPB, SRSF3
    Protein Size: 545
    分子量
    58 kDa
    基因ID
    326
    NCBI登录号
    NM_000383, NP_000374
    UniProt
    O43918
    途径
    Chromatin Binding
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