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OTX2 抗体 (N-Term)

This anti-OTX2 antibody is a 兔 多克隆 antibody detecting OTX2 in WB 和 IHC. Suitable for 人, 大鼠, 小鼠, 斑马鱼, 犬, 绵羊, 兔, 马, Cow 和 豚鼠. This Primary Antibody has been cited in 3+ publications.
产品编号 ABIN2779643
发货至: 中国

Quick Overview for OTX2 抗体 (N-Term) (ABIN2779643)

抗原

See all OTX2 抗体
OTX2 (Orthodenticle Homeobox 2 (OTX2))

适用

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人, 大鼠, 小鼠, 斑马鱼, 犬, 绵羊, 兔, 马, Cow, 豚鼠

宿主

  • 53
  • 4

克隆类型

  • 51
  • 6
多克隆

标记

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This OTX2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

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    N-Term

    序列

    PESRVQVWFK NRRAKCRQQQ QQQQNGGQNK VRPAKKKTSP AREVSSESGT

    预测反应

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

    产品特性

    This is a rabbit polyclonal antibody against OTX2. It was validated on Western Blot and immunohistochemistry.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N terminal region of human OTX2
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 297 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Machali?ska, Kawa, Pius-Sadowska, Rogi?ska, K?os, Baumert, Wiszniewska, Machali?ski: "Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: an insight into the role of glial cells in retinal repair." in: Experimental eye research, Vol. 112, pp. 68-78, (2013) (PubMed).

    Aluigi, Angelini, Corte, Falugi: "The sea urchin, Paracentrotus lividus, embryo as a "bioethical" model for neurodevelopmental toxicity testing: effects of diazinon on the intracellular distribution of OTX2-like proteins." in: Cell biology and toxicology, Vol. 24, Issue 6, pp. 587-601, (2008) (PubMed).

    Takeda, Yokoyama, Yasumoto, Saito, Udono, Takahashi, Shibahara: "OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium." in: Biochemical and biophysical research communications, Vol. 300, Issue 4, pp. 908-14, (2003) (PubMed).

  • 抗原

    OTX2 (Orthodenticle Homeobox 2 (OTX2))

    别名

    OTX2

    背景

    Homeobox protein OTX2 is a member of the bicoid sub-family of homeodomain-containing transcription factors. This protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined. This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.
    Alias Symbols: MCOPS5, MGC45000, CPHD6
    Protein Interaction Partner: ATXN1, CDK4, APP, DMBX1, TLE4, FOXA2, MITF, OTX2, LHX1,
    Protein Size: 297

    分子量

    32 kDa

    基因ID

    5015

    NCBI登录号

    NM_021728, NP_068374

    途径

    Dopaminergic Neurogenesis
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