Calreticulin 抗体 (C-Term)
Quick Overview for Calreticulin 抗体 (C-Term) (ABIN2779285)
抗原
See all Calreticulin (CALR) 抗体适用
宿主
克隆类型
标记
应用范围
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                                            抗原表位
- C-Term
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                                            序列
- FGNETWGVTK AAEKQMKDKQ DEEQRLKEEE EDKKRKEEEE AEDKEDDEDK
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                                            预测反应
- Dog: 100%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Yeast: 92%, Zebrafish: 79%
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                                            产品特性
- This is a rabbit polyclonal antibody against CALR. It was validated on Western Blot using a cell lysate as a positive control.
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                                            纯化方法
- Affinity Purified
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                                            免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human CALR
 
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                                            应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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                                            说明
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                        Antigen size: 417 AA 
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            浓度
- Lot specific
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                                            缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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                                            储存液
- Sodium azide
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                                            注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            注意事项
- Avoid repeated freeze-thaw cycles.
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                                            储存条件
- -20 °C
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                                            储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
 
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    - 
                                            : "MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas."    in: Cancer prevention research (Philadelphia, Pa.), Vol. 8, Issue 11, pp. 1112-9, (2015)         (PubMed).        
 
 
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                                            : "MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas."    in: Cancer prevention research (Philadelphia, Pa.), Vol. 8, Issue 11, pp. 1112-9, (2015)         (PubMed).        
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    - Calreticulin (CALR)
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                                            别名
- CALR
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                                            背景
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                        Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.
 Alias Symbols: RO, CRT, SSA, cC1qR
 Protein Interaction Partner: HUWE1, UBC, LGR4, MDM2, RNF2, SUZ12, rev, AARSD1, THG1L, NSUN2, SH3GLB1, EEF2K, ARPC1A, ANP32B, ACTR2, ARPC1B, ARPC3, ARPC5, TPD52L2, SH3GL1, RPA3, RPA1, PRKACA, PFDN5, LPP, PARK2, UPF2, UBD, SOX2, PDIA3, CLN5, ITGA3, HLA-E, HLA-A, CALR, SLC27A2, env, MTN
 Protein Size: 417
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                                            分子量
- 48 kDa
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                                            基因ID
- 811
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                                            NCBI登录号
- NM_004343, NP_004334
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                                            UniProt
- P27797
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                                            途径
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response
 抗原
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