CPSF4 抗体 (C-Term)
Quick Overview for CPSF4 抗体 (C-Term) (ABIN2779005)
抗原
See all CPSF4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- SLIQLTSQNS SPNQQRTPQV IGVMQSQNSS AGNRGPRPLE QVTCYKCGEK
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预测反应
- Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against CPSF4. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human CPSF4
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anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 1-244) antibody
CPSF4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 81-180) antibodyCPSF4 适用: 人, 小鼠 WB, ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (C-Term) antibodyCPSF4 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) antibodyCPSF4 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 1-243) antibodyCPSF4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (C-Term) antibodyCPSF4 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 31-216) antibodyCPSF4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (C-Term) antibodyCPSF4 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 216 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))
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别名
- CPSF4
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背景
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Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.
Alias Symbols: CPSF30, NAR, NEB1
Protein Interaction Partner: FIP1L1, RBBP6, MEOX2, CLK2, NPM1, MDC1, ECT2, UBC, CSTF2T, RRAGA, CDC73, SLC12A9, MARK3,
Protein Size: 216 -
分子量
- 24 kDa
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基因ID
- 10898
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NCBI登录号
- NM_001081559
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UniProt
- O95639
抗原
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