SF3A1 抗体 (N-Term)
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北京 101111
Quick Overview for SF3A1 抗体 (N-Term) (ABIN2778958)
抗原
See all SF3A1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- QQTTQQQLPQ KVQAQVIQET IVPKEPPPEF EFIADPPSIS AFDLDVVKLT
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
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产品特性
- This is a rabbit polyclonal antibody against SF3A1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human SF3A1
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anti-Splicing Factor 3a, Subunit 1 (SF3A1) (AA 249-568) antibody
SF3A1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4D8 unconjugated
anti-Splicing Factor 3a, Subunit 1 (SF3A1) (AA 443-793) antibodySF3A1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Splicing Factor 3a, Subunit 1 (SF3A1) (AA 249-568) antibodySF3A1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 8H1 unconjugated
anti-Splicing Factor 3a, Subunit 1 (SF3A1) (AA 1-793) antibodySF3A1 适用: 人, 小鼠, 大鼠, 哺乳动物 WB, IHC, IP, IHC (p), ICC 宿主: 小鼠 Monoclonal 85D5 unconjugated
anti-Splicing Factor 3a, Subunit 1 (SF3A1) (AA 140-227) antibodySF3A1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Splicing Factor 3a, Subunit 1 (SF3A1) (AA 72-121) antibodySF3A1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠, 非洲爪蟾, 小鸡, Pig, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Splicing Factor 3a, Subunit 1 (SF3A1) (AA 121-170) antibodySF3A1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 斑马鱼, 豚鼠, 非洲爪蟾, Pig, Bat, Hamster, 猴, Drosophila melanogaster WB 宿主: 兔 Polyclonal unconjugated
anti-Splicing Factor 3a, Subunit 1 (SF3A1) (AA 249-568) antibodySF3A1 适用: 人 WB 宿主: 小鼠 Monoclonal 7G6 unconjugated
anti-Splicing Factor 3a, Subunit 1 (SF3A1) (N-Term) antibodySF3A1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 793 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
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: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
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- SF3A1 (Splicing Factor 3a, Subunit 1 (SF3A1))
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别名
- SF3A1
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背景
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SF3A1 is the subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family, named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs.This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family, named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: PRP21, PRPF21, SAP114, SF3A120
Protein Interaction Partner: HDAC1, FUS, HUWE1, UBC, RPA3, RPA2, RPA1, WWOX, ZBTB1, SUZ12, EED, RNF2, rev, NR3C1, APBB1, HNRNPR, GAS7, CCDC6, PPP4R2, BRCC3, SMEK1, PRPF40A, GAPVD1, WBP4, TCERG1, HDAC11, HDAC6, SF3A3, DDX42, RBM10, SF3A2, SF1, WHSC1, IL7R, CSNK2A1, WDR77, RBFOX2, SMUR
Protein Size: 793 -
分子量
- 89 kDa
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基因ID
- 10291
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NCBI登录号
- NM_005877, NP_005868
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UniProt
- Q15459
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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