PRMT2 抗体 (N-Term)
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北京 101111
Quick Overview for PRMT2 抗体 (N-Term) (ABIN2778662)
抗原
See all PRMT2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- PRMT2 Antibody - N-terminal region
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序列
- ERAGCCGYIP ANHVGKHVDE YDPEDTWQDE EYFGSYGTLK LHLEMLADQP
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预测反应
- Human: 100%, Rat: 79%
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产品特性
- This is a rabbit polyclonal antibody against PRMT2. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT2
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anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibody
PRMT2 适用: 人, 大鼠, 小鼠, Cow, 马, 豚鼠, Pig, 犬, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (AA 22-53) antibodyPRMT2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (AA 22-53), (N-Term) antibodyPRMT2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0027 unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (AA 1-300) antibodyPRMT2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) antibodyPRMT2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (AA 1-433) antibodyPRMT2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibodyPRMT2 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (AA 344-375), (C-Term) antibodyPRMT2 适用: 人 WB 宿主: 兔 Polyclonal RB0191 unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibodyPRMT2 适用: 人, 大鼠, 小鼠, Cow, 马, Bat, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibodyPRMT2 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40195-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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: "Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein." in: Oncogene, Vol. 33, Issue 48, pp. 5546-58, (2014) (PubMed).
: "PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor." in: The Journal of steroid biochemistry and molecular biology, Vol. 107, Issue 1-2, pp. 1-14, (2007) (PubMed).
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- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
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别名
- PRMT2
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背景
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Background Information: The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Gene Name: Protein arginine methyltransferase 2
Alternative Symbols: HRMT1L1
Protein Name: Protein arginine N-methyltransferase 2
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分子量
- 49kDa
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基因ID
- 3275
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NCBI登录号
- NP_001526
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UniProt
- P55345
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding
抗原
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