HDAC4 抗体 (Middle Region)
Quick Overview for HDAC4 抗体 (Middle Region) (ABIN2778342)
抗原
See all HDAC4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- YLDRLPGQKE AHAQAGVQVK QEPIESDEEE AEPPREVEPG QRQPSEQELL
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预测反应
- Cow: 100%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against HDAC4. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human HDAC4
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 1084 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- HDAC4 (Histone Deacetylase 4 (HDAC4))
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别名
- HDAC4
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背景
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC4 belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HA6116, HD4, HDAC-A, HDACA, KIAA0288, AHO3, BDMR, HDAC-4
Protein Interaction Partner: UBC, TP53BP1, KRT31, MTUS2, KDM5B, HDAC5, NCOR2, PNMA1, KRT38, YWHAG, KRT40, CCDC136, RINT1, ANKRA2, EFEMP2, LDOC1, GSK3B, GOLGA2, CDR2, BCL6, YWHAQ, YWHAB, YWHAE, SIRT1, UBE2I, TBL1XR1, HDAC4, NCOR1, YWHAZ, YWHAH, SFN, MIF4GD, ZBTB7B, APP, ATF3, JDP2, Bt
Protein Size: 1084 -
分子量
- 119 kDa
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基因ID
- 9759
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NCBI登录号
- NM_006037, NP_006028
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UniProt
- P56524
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process
抗原
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