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GSTM1 抗体 (N-Term)

This anti-GSTM1 antibody is a 兔 多克隆 antibody detecting GSTM1 in WB. Suitable for 人, 小鼠, 大鼠, 犬, Cow, 兔, 豚鼠, 马, 山羊 和 绵羊. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN2776984
发货至: 中国

Quick Overview for GSTM1 抗体 (N-Term) (ABIN2776984)

抗原

See all GSTM1 抗体
GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

适用

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人, 小鼠, 大鼠, 犬, Cow, 兔, 豚鼠, 马, 山羊, 绵羊

宿主

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克隆类型

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多克隆

标记

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This GSTM1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    N-Term

    序列

    KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL PYLIDGAHKI TQSNAILCYI

    预测反应

    Cow: 100%, Dog: 100%, Goat: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%

    产品特性

    This is a rabbit polyclonal antibody against GSTM1. It was validated on Western Blot using a cell lysate as a positive control.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N terminal region of human GSTM1
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 218 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Zachut, Kra, Livshitz, Portnick, Yakoby, Friedlander, Levin: "Seasonal heat stress affects adipose tissue proteome toward enrichment of the Nrf2-mediated oxidative stress response in late-pregnant dairy cows." in: Journal of proteomics, Vol. 158, pp. 52-61, (2017) (PubMed).

    Bates, Li, Liang, Sarojini, An, Masternak, Bartke, Wang: "MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging." in: Aging cell, Vol. 9, Issue 1, pp. 1-18, (2010) (PubMed).

  • 抗原

    GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

    别名

    GSTM1

    背景

    Cytosolic and membrane-bound forms of glutathione S-transferase are two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. GSTM1 a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
    Alias Symbols: GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MGC26563, MU, MU-1
    Protein Interaction Partner: GSTM3, UBC, IQCB1, MAP3K5, GSTM2, GSTM1,
    Protein Size: 218

    分子量

    26 kDa

    基因ID

    2944

    NCBI登录号

    NM_000561, NP_000552

    UniProt

    P46439

    途径

    Negative Regulation of Transporter Activity
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