ACTN2 抗体 (C-Term)
Quick Overview for ACTN2 抗体 (C-Term) (ABIN2776830)
抗原
See all ACTN2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- VIASFRILAS DKPYILAEEL RRELPPDQAQ YCIKRMPAYS GPGSVPGALD
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
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产品特性
- This is a rabbit polyclonal antibody against ACTN2. It was validated on Western Blot and immunohistochemistry.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human ACTN2
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anti-Actinin, alpha 2 (ACTN2) antibody
ACTN2 适用: 人 WB, IHC, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 2 (ACTN2) (AA 1-254) antibodyACTN2 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 2 (ACTN2) (AA 557-692) antibodyACTN2 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal ACTN2-3293 unconjugated
anti-Actinin, alpha 2 (ACTN2) (AA 557-692) antibodyACTN2 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal ACTN2-3292 unconjugated
anti-Actinin, alpha 2 (ACTN2) (AA 557-692) antibodyACTN2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ACTN2-3291 unconjugated
anti-Actinin, alpha 2 (ACTN2) (N-Term) antibodyACTN2 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 2 (ACTN2) antibodyACTN2 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 2 (ACTN2) (AA 11-347) antibodyACTN2 适用: 人, 小鼠 WB, IHC, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 2 (ACTN2) (AA 1-250) antibodyACTN2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 2 (ACTN2) (C-Term) antibodyACTN2 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 894 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- ACTN2 (Actinin, alpha 2 (ACTN2))
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别名
- ACTN2
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背景
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The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Transcript variants resulting from the use of multiple poly_A sites have been observed.
Alias Symbols: CMD1AA
Protein Interaction Partner: ACTN2, FAM154A, BRMS1L, MICALL2, MYOZ2, PDLIM3, SP100, SNAI1, MOS, RTP5, SYNPO2, SUMO1, IGSF8, ERBB2IP, CAPN1, ZNF446, RPL35, UBC, NOS3, ACTN1, ACTN4, FBXL22, COIL, SUMO3, ATXN2, KCNA5, LDB3, KCNN2, PSMA3, ITGB3BP, SNW1, MED14, NR1I2, KAT2B, NRIP1, ATXN7,
Protein Size: 894 -
分子量
- 98 kDa
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基因ID
- 88
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NCBI登录号
- NM_001103, NP_001094
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UniProt
- P35609
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途径
- Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
抗原
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