Uromodulin 抗体 (C-Term)
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北京 101111
Quick Overview for Uromodulin 抗体 (C-Term) (ABIN2776813)
抗原
See all Uromodulin (UMOD) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- UMOD Antibody - C-terminal region
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序列
- PTCSGTRFRS GSVIDQSRVL NLGPITRKGV QATVSRAFSS LGLLKVWLPL
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预测反应
- Cow: 91%, Dog: 86%, Human: 100%, Mouse: 85%
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产品特性
- This is a rabbit polyclonal antibody against UMOD. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human UMOD
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anti-Uromodulin (UMOD) (AA 351-450) antibody
UMOD 适用: 人 WB, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Uromodulin (UMOD) (AA 25-120) antibodyUMOD 适用: 人 WB, IP, ELISA 宿主: 小鼠 Monoclonal 3F10 unconjugated
anti-Uromodulin (UMOD) (AA 32-151) antibodyUMOD 适用: 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Uromodulin (UMOD) (AA 1-611) antibodyUMOD 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Uromodulin (UMOD) (AA 1-611) antibodyUMOD 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Uromodulin (UMOD) antibodyUMOD 适用: 人, 犬 IHC, IF, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal 10-32 unconjugated
anti-Uromodulin (UMOD) (AA 334-589) antibodyUMOD 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Uromodulin (UMOD) (C-Term) antibodyUMOD 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Uromodulin (UMOD) (C-Term) antibodyVerified UMOD 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Uromodulin (UMOD) (AA 525-536) antibodyVerified UMOD 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41437-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- Uromodulin (UMOD)
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别名
- UMOD
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背景
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Background Information: This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Gene Name: Uromodulin
Alternative Symbols: THP, FJHN, HNFJ, THGP, HNFJ1, MCKD2, ADTKD1, ADMCKD2
Protein Name: Uromodulin
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分子量
- 67kDa
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基因ID
- 7369
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NCBI登录号
- NP_001008390
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UniProt
- P07911
抗原
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