Zona Pellucida Glycoprotein 3 抗体 (C-Term)
(2 references)Quick Overview for Zona Pellucida Glycoprotein 3 抗体 (C-Term) (ABIN2776494)
抗原
See all Zona Pellucida Glycoprotein 3 (ZP3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- NKGDCGTPSH SRRQPHVMSQ WSRSASRNRR HVTEEADVTV GATDLPGQEW
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预测反应
- Cow: 100%, Horse: 100%, Human: 100%, Rabbit: 100%, Rat: 90%
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产品特性
- This is a rabbit polyclonal antibody against ZP3. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human ZP3
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anti-Zona Pellucida Glycoprotein 3 (ZP3) (AA 250-350) antibody
ZP3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Zona Pellucida Glycoprotein 3 (ZP3) (AA 170-390) antibodyZP3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Zona Pellucida Glycoprotein 3 (ZP3) (AA 1-373) antibodyZP3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Zona Pellucida Glycoprotein 3 (ZP3) (C-Term) antibodyZP3 适用: 人, Cow, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Zona Pellucida Glycoprotein 3 (ZP3) (AA 353-380), (C-Term) antibodyZP3 适用: 人 WB 宿主: 兔 Polyclonal RB36988 unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 424 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Morphometric characteristics of preantral and antral follicles and expression of factors involved in folliculogenesis in ovaries of adult baboons (Papio anubis)." in: Journal of assisted reproduction and genetics, Vol. 33, Issue 5, pp. 617-626, (2016) (PubMed).
: "Zona pellucida components are present in human fetal ovary before follicle formation." in: Molecular and cellular endocrinology, Vol. 289, Issue 1-2, pp. 10-5, (2008) (PubMed).
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: "Morphometric characteristics of preantral and antral follicles and expression of factors involved in folliculogenesis in ovaries of adult baboons (Papio anubis)." in: Journal of assisted reproduction and genetics, Vol. 33, Issue 5, pp. 617-626, (2016) (PubMed).
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- Zona Pellucida Glycoprotein 3 (ZP3)
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别名
- ZP3
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背景
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The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene
Alias Symbols: ZPC, ZP3A, ZP3B, Zp-3
Protein Interaction Partner: HECW2, OR2L13, SPACA3, MICALL1, MRPS16, PCDH17, UBAP2L, UBC, ENGASE, ACR, FURIN,
Protein Size: 424 -
分子量
- 47 kDa
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基因ID
- 7784
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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