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ZIC2 抗体 (C-Term)

This anti-ZIC2 antibody is a 兔 多克隆 antibody detecting ZIC2 in WB 和 IHC. Suitable for 人, 大鼠, 小鼠 和 豚鼠. This Primary Antibody has been cited in 4+ publications.
产品编号 ABIN2776475
发货至: 中国

Quick Overview for ZIC2 抗体 (C-Term) (ABIN2776475)

抗原

See all ZIC2 抗体
ZIC2

适用

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人, 大鼠, 小鼠, 豚鼠

宿主

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克隆类型

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多克隆

标记

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This ZIC2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

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    C-Term

    序列

    EPQSSSNLSP AAAAAAAAAA AAAAAVSAVH RGGGSGSGGA GGGSGGGSGS

    预测反应

    Guinea Pig: 87%, Human: 100%, Mouse: 85%, Rat: 92%

    产品特性

    This is a rabbit polyclonal antibody against ZIC2. It was validated on Western Blot and immunohistochemistry.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the C terminal region of human ZIC2
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 532 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Toth, Schiffmann, Hube-Magg, Büscheck, Höflmayer, Weidemann, Lebok, Fraune, Minner, Schlomm, Sauter, Plass, Assenov, Simon, Meiners, Gerhäuser: "Random forest-based modelling to detect biomarkers for prostate cancer progression." in: Clinical epigenetics, Vol. 11, Issue 1, pp. 148, (2020) (PubMed).

    Inaguma, Ito, Riku, Ikeda, Kasai: "Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2." in: Oncotarget, Vol. 6, Issue 29, pp. 28257-68, (2015) (PubMed).

    Zhu, Wang, He, Huang, Du, Zhang, Yan, Xia, Ye, Wang, Hao, Wu, Fan: "ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells." in: The Journal of clinical investigation, Vol. 125, Issue 10, pp. 3795-808, (2015) (PubMed).

    McCampbell, Truong, Broom, Allchorne, Gable, Cutler, Mattson, Woolf, Frosch, Harmon, Dunn, Brown: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." in: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, (2005) (PubMed).

  • 抗原

    ZIC2

    别名

    ZIC2

    背景

    ZIC2 is a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects.This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
    Alias Symbols: HPE5
    Protein Interaction Partner: SUMO1, ELAVL1, GLI3, GLI2, GLI1, RNF180, UBC,
    Protein Size: 532

    分子量

    55 kDa

    基因ID

    7546

    NCBI登录号

    NM_007129, NP_009060

    UniProt

    O95409

    途径

    Tube Formation
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