ZIC2 抗体 (C-Term)
(4 references)Quick Overview for ZIC2 抗体 (C-Term) (ABIN2776475)
抗原
See all ZIC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- EPQSSSNLSP AAAAAAAAAA AAAAAVSAVH RGGGSGSGGA GGGSGGGSGS
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预测反应
- Guinea Pig: 87%, Human: 100%, Mouse: 85%, Rat: 92%
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产品特性
- This is a rabbit polyclonal antibody against ZIC2. It was validated on Western Blot and immunohistochemistry.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human ZIC2
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anti-ZIC2 (ZIC2) (AA 446-495) antibody
ZIC2 适用: 人, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-ZIC2 (ZIC2) antibodyZIC2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-ZIC2 (ZIC2) (C-Term) antibodyVerified ZIC2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-ZIC2 (ZIC2) (AA 130-220) antibodyZIC2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H7 unconjugated
anti-ZIC2 (ZIC2) (AA 151-216) antibodyZIC2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C12 unconjugated
anti-ZIC2 (ZIC2) (AA 350-400) antibodyZIC2 适用: 人, 小鼠, 犬, 猴, Cow, 小鸡, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-ZIC2 (ZIC2) (AA 1-220) antibodyZIC2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 532 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Random forest-based modelling to detect biomarkers for prostate cancer progression." in: Clinical epigenetics, Vol. 11, Issue 1, pp. 148, (2020) (PubMed).
: "Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2." in: Oncotarget, Vol. 6, Issue 29, pp. 28257-68, (2015) (PubMed).
: "ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells." in: The Journal of clinical investigation, Vol. 125, Issue 10, pp. 3795-808, (2015) (PubMed).
: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." in: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, (2005) (PubMed).
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: "Random forest-based modelling to detect biomarkers for prostate cancer progression." in: Clinical epigenetics, Vol. 11, Issue 1, pp. 148, (2020) (PubMed).
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- ZIC2
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别名
- ZIC2
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背景
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ZIC2 is a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects.This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
Alias Symbols: HPE5
Protein Interaction Partner: SUMO1, ELAVL1, GLI3, GLI2, GLI1, RNF180, UBC,
Protein Size: 532 -
分子量
- 55 kDa
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基因ID
- 7546
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NCBI登录号
- NM_007129, NP_009060
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UniProt
- O95409
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途径
- Tube Formation
抗原
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