HSBP1 抗体 (N-Term)
(1 reference)Quick Overview for HSBP1 抗体 (N-Term) (ABIN2776380)
抗原
See all HSBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- AETDPKTVQD LTSVVQTLLQ QMQDKFQTMS DQIIGRIDDM SSRIDDLEKN
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 100%, Rat: 93%, Zebrafish: 86%
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产品特性
- This is a rabbit polyclonal antibody against HSBP1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human HSBP1
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anti-Heat Shock Factor Binding Protein 1 (HSBP1) (AA 1-75) antibody
HSBP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock Factor Binding Protein 1 (HSBP1) (AA 1-76) antibodyHSBP1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2C3 unconjugated
anti-Heat Shock Factor Binding Protein 1 (HSBP1) antibody (Biotin)HSBP1 适用: 人 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal Biotin
anti-Heat Shock Factor Binding Protein 1 (HSBP1) antibody (FITC)HSBP1 适用: 人 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal FITC
anti-Heat Shock Factor Binding Protein 1 (HSBP1) antibody (HRP)HSBP1 适用: 人 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal HRP
anti-Heat Shock Factor Binding Protein 1 (HSBP1) antibodyHSBP1 适用: 人, 小鼠, 大鼠, Cow, Pig WB, ICC, IF 宿主: 小鸡 Polyclonal unconjugated
anti-Heat Shock Factor Binding Protein 1 (HSBP1) antibodyHSBP1 适用: 人, 小鼠, 大鼠, Cow, Pig WB, ICC, IF 宿主: 小鼠 Monoclonal 6H11 unconjugated
anti-Heat Shock Factor Binding Protein 1 (HSBP1) (N-Term) antibodyHSBP1 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 马, 兔, 斑马鱼, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 76 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 735-45, (2002) (PubMed).
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: "Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 735-45, (2002) (PubMed).
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- HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))
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别名
- HSBP1
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背景
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The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.
Alias Symbols: DKFZp686D1664, DKFZp686O24200, NPC-A-13
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-7, LNX1, KIAA1217, CCHCR1, CCDC53, SDCBP, KIFC3, HSBP1, UBC, VCP, RRBP1, RB1CC1, HSF1, HSPA1A, HSPA4,
Protein Size: 76 -
分子量
- 8 kDa
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基因ID
- 3281
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NCBI登录号
- NM_001537, NP_001528
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UniProt
- O75506
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途径
- SARS-CoV-2 Protein Interactome
抗原
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