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CREM 抗体 (N-Term)

CREM 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 绵羊, 豚鼠, 马, 斑马鱼, 山羊 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2776016
发货至: 中国
  • 抗原 See all CREM 抗体
    CREM (CAMP Responsive Element Modulator (CREM))
    抗原表位
    • 16
    • 15
    • 15
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 42
    • 40
    • 24
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 犬, 兔, 绵羊, 豚鼠, 马, 斑马鱼, 山羊
    宿主
    • 54
    • 3
    • 1
    克隆类型
    • 56
    • 1
    多克隆
    标记
    • 25
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This CREM antibody is un-conjugated
    应用范围
    • 36
    • 26
    • 26
    • 21
    • 18
    • 7
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    序列
    MAAATGDMPT YQIRAPTAAL PQGVVMAASP GSLHSPQQLA EEATRKRELR
    预测反应
    Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 79%
    产品特性
    This is a rabbit polyclonal antibody against CREM. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Protein A purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human CREM
    Top Product
    Discover our top product CREM Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 120 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Sunahori, Juang, Tsokos: "Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 3, pp. 1500-8, (2009) (PubMed).

    Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

  • 抗原
    CREM (CAMP Responsive Element Modulator (CREM))
    别名
    CREM (CREM 产品)
    别名
    CREM antibody, ICER antibody, CREM-2 antibody, hCREM-2 antibody, ICERI antibody, Icer antibody, cAMP responsive element modulator antibody, CREM antibody, Crem antibody
    背景
    CREM is a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
    Alias Symbols: ICER, CREM-2, hCREM-2
    Protein Interaction Partner: CREB1, PIAS3, CASP8AP2, UBE2I, UBC, SP100, ATXN1, EMP3, HHV8GK18_gp81, MAPK3, CREB3L4, HDAC1, CREB3L1, TAF4, CAMK2D, GSK3A, FHL5, GSK3B, KCNIP3, CAMK2G, PRKACA, CSNK1A1, CREBBP, TBP, PRKCA, SPI1, CREM, ATF1, CDC34, CDK1, CSNK2A2, CSNK2A1, CD34,
    Protein Size: 120
    分子量
    13 kDa
    基因ID
    1390
    NCBI登录号
    NM_182717, NP_874386
    UniProt
    O75519
    途径
    Retinoic Acid Receptor Signaling Pathway
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