NFX1 抗体 (N-Term)
Quick Overview for NFX1 抗体 (N-Term) (ABIN2776010)
抗原
See all NFX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS
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预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%
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产品特性
- This is a rabbit polyclonal antibody against NFX1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human NFX1
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anti-Nuclear Transcription Factor, X-Box Binding 1 (NFX1) (AA 981-1080) antibody
NFX1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1D12 unconjugated
anti-Nuclear Transcription Factor, X-Box Binding 1 (NFX1) (C-Term) antibodyNFX1 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 猴 WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Transcription Factor, X-Box Binding 1 (NFX1) (N-Term) antibodyNFX1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Transcription Factor, X-Box Binding 1 (NFX1) (Middle Region) antibodyNFX1 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 1024 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))
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别名
- NFX1
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背景
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NFX1 binds to the X-box motif of MHC class II genes and represses their expression. NFX1 may play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. NFX1 mediates E2-dependent ubiquitination.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
Alias Symbols: DKFZp779G2416, MGC20369, NFX2
Protein Interaction Partner: UBC, BMI1, HECW2, SRSF4, SRSF3, RPS19, RPS3A, RPL22, RPL17, RPL13, RPL7A, RPL6, RPL3, PABPC3, YBX1, NCL, HNRNPM, HSPA1A, HNRNPU, HNRNPH1, HNRNPA2B1, HIST1H2AE, EEF1A2, DMD, DDX5, FAM208B, PABPC1, RPL13A, LARP1, APC2, MATR3, HIST1H4E, USP9X, SIN3A, MAML3,
Protein Size: 1024 -
分子量
- 113 kDa
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基因ID
- 4799
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NCBI登录号
- NM_147133, NP_667344
抗原
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