CBX3 抗体 (Middle Region)
Quick Overview for CBX3 抗体 (Middle Region) (ABIN2775975)
抗原
See all CBX3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- WEPEENLDCP ELIEAFLNSQ KAGKEKDGTK RKSLSDSESD DSKSKKKRDA
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against CBX3. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human CBX3
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 183 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- CBX3 (Chromobox Homolog 3 (CBX3))
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别名
- CBX3
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背景
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At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. CBX3 binds DNA and is a component of heterochromatin. CBX3 also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of CBX3 may explain the association of heterochromatin with the inner nuclear membrane.At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Alias Symbols: HECH, HP1-GAMMA, HP1Hs-gamma
Protein Interaction Partner: UBC, SUMO1, MDM2, EED, SUZ12, RNF2, WDR1, DCK, ADSS, THOP1, TALDO1, PTMS, OXCT1, IDH1, HSPE1, HECW2, PARK2, VHL, CHAF1A, AURKB, AURKA, EHMT2, FN1, TRIM39, HNF1A, CBX5, MDC1, TP53BP1, YWHAE, TNKS1BP1, H2AFY, ATXN7L2, CACNB4, BAHD1, CUL1, PCGF6, SIRT7, RYBP
Protein Size: 183 -
分子量
- 21 kDa
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基因ID
- 11335
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NCBI登录号
- NM_007276, NP_009207
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UniProt
- Q13185
抗原
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