KLHL12 抗体 (N-Term)
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- 抗原 See all KLHL12 抗体
- KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 斑马鱼, 豚鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KLHL12 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- EKGKPYVDIQ GLTASTMEIL LDFVYTETVH VTVENVQELL PAACLLQLKG
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
- 产品特性
- This is a rabbit polyclonal antibody against KLHL12. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human KLHL12
- Top Product
- Discover our top product KLHL12 Primary Antibody
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anti-Kelch-Like 12 (Drosophila) (KLHL12) (AA 1-220) antibody
KLHL12 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 12 (Drosophila) (KLHL12) antibodyKLHL12 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Kelch-Like 12 (Drosophila) (KLHL12) (N-Term) antibodyKLHL12 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 斑马鱼, 豚鼠, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 12 (Drosophila) (KLHL12) (AA 81-341) antibodyKLHL12 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 12 (Drosophila) (KLHL12) (AA 376-404), (C-Term) antibodyKLHL12 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB37184 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeat freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))
- 别名
- KLHL12 (KLHL12 产品)
- 别名
- zgc:92570 antibody, wu:fi60g03 antibody, C3ip1 antibody, C3IP1 antibody, DKIR antibody, hDKIR antibody, Ski2 like RNA helicase antibody, kelch like family member 12 L homeolog antibody, kelch like family member 12 antibody, kelch-like family member 12 antibody, kelch-like 12 antibody, SKIV2L antibody, klhl12.L antibody, KLHL12 antibody, klhl12 antibody, Klhl12 antibody
- 背景
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KLHL12 is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.
Alias Symbols: C3IP1, DKIR, hDKIR
Protein Interaction Partner: PEF1, TBC1D10C, FGD2, SYNE4, CCBE1, TTBK2, RPP25L, GLYCTK, MRPL10, SNX20, C1QTNF2, ZBP1, KLHL12, WDYHV1, PRR13, CARD10, KLHL3, INMT, CUL3, BAG6, VEGFB, UBE2I, SDCBP, PDGFRB, MPP1, FLNA, TAOK2, DGCR6, DROSHA, EZH2, KLHL2, DVL3, UBC, ATXN1, CAND1, DCUN1D1,
Protein Size: 568 - 分子量
- 63 kDa
- 基因ID
- 59349
- NCBI登录号
- NM_021633, NP_067646
- UniProt
- Q53G59
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