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GNAS 抗体 (N-Term)

Name: GNAS 抗体 (N-Term)
SKU: ABIN2775542
Availability: OutOfStock

This anti-GNAS antibody is a 兔多克隆 antibody detecting GNAS in WB 和 IHC. Suitable for 人, 小鼠, 大鼠, 犬, Cow, 兔, 马和豚鼠. This Primary Antibody has been cited in 2+ publications.

Host: Rabbit Target Name: GNAS Sample Tissue: MCF7 Whole Cell Lane A: Primary Antibody Lane B: Primary Antibody + Blocking Peptide Primary Antibody Concentration: 1 µg/mL Peptide Concentration: 5 µg/mL Lysate Quantity: 41 µg/laneGel Concentration:. (GNAS 抗体 (N-Term))

Immunohistochemistry (IHC) image for anti-GNAS Complex Locus (GNAS) (N-Term) antibody (ABIN2775542) (GNAS 抗体 (N-Term))

IHC

Lanes : Lane 1: INS1 lysate Primary Antibody Dilution : 1:1000 Secondary Antibody : Donkey anti-rabbit-HRP Secondary Antibody Dilution : 1:1000 Gene Name : GNAS Submitted by : Olivier Costa, Diabetes research center VUB (GNAS 抗体 (N-Term))

Host: Rabbit Target Name: GNAS Sample Tissue: Human Jurkat Whole Cell Antibody Dilution: 1ug/ml (GNAS 抗体 (N-Term))

Host: Rabbit Target Name: GNAS Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml (GNAS 抗体 (N-Term))

WB Suggested Anti-GNAS Antibody Titration: 1 ug/ml Positive Control: MCF-7 whole cell lysates GNAS is strongly supported by BioGPS gene expression data to be expressed in Human MCF7 cells (GNAS 抗体 (N-Term))

Host: Rabbit Target Name: GNAS Sample Tissue: Human Lung Tumor Antibody Dilution: 1. (GNAS 抗体 (N-Term))

Anti-GNAS antibody IHC staining of human thyroid. (GNAS 抗体 (N-Term))

IHC

Rabbit Anti-GNAS Antibody arp42693 Paraffin Embedded Tissue: Human Pancreas Antibody Concentration: 5 ug/ml (GNAS 抗体 (N-Term))

IHC

9 images

(2 references)

产品编号 ABIN2775542

发货至: 中国

Quick Overview for GNAS 抗体 (N-Term) (ABIN2775542)

抗原

See all GNAS 抗体

GNAS (GNAS Complex Locus (GNAS))

适用

人, 小鼠, 大鼠, 犬, Cow, 兔, 马, 豚鼠

宿主

兔

克隆类型

多克隆

标记

This GNAS antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product GNAS Primary Antibody

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N-Term

序列

VYRATHRLLL LGAGESGKST IVKQMRILHV NGFNGEGGEE DPQAARSNSD

预测反应

Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

产品特性

This is a rabbit polyclonal antibody against GNAS. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human GNAS
anti-GNAS Complex Locus (GNAS) (AA 42-188) antibody
GNAS 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2A2B7 unconjugated

anti-GNAS Complex Locus (GNAS) antibody
KO Validated GNAS 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) (AA 42-188) antibody
GNAS 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 7G6G5 unconjugated

anti-GNAS Complex Locus (GNAS) (N-Term) antibody
GNAS 适用: 人, 小鼠, 大鼠, Cow, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) (AA 310-404) antibody
GNAS 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) (Internal Region) antibody
Verified GNAS 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) (AA 1-394) antibody
GNAS 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) (AA 287-315), (C-Term) antibody
GNAS 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB33001 unconjugated

anti-GNAS Complex Locus (GNAS) (AA 286-315), (C-Term) antibody
GNAS 适用: 人 WB, IF, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

anti-GNAS Complex Locus (GNAS) (AA 1-394) antibody
GNAS 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 394 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Moreno-Smith, Lee, Lu, Nagaraja, He, Rupaimoole, Han, Jennings, Roh, Nishimura, Kang, Allen, Armaiz, Matsuo, Shahzad, Bottsford-Miller, Langley, Cole, Lutgendorf, Siddik, Sood: "Biologic effects of dopamine on tumor vasculature in ovarian carcinoma." in: Neoplasia (New York, N.Y.), Vol. 15, Issue 5, pp. 502-10, (2013) (PubMed).

Masyuk, Huang, Radtke, Gajdos, Splinter, Masyuk, Gradilone, LaRusso: "Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 304, Issue 11, pp. G1013-24, (2013) (PubMed).
抗原

GNAS (GNAS Complex Locus (GNAS))

别名

GNAS

背景

Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
Alias Symbols: AHO, C20orf45, GNAS1, GPSA, GSA, GSP, MGC33735, PHP1A, PHP1B, POH, dJ309F20.1.1, dJ806M20.3.3, NESP, PHP1C
Protein Interaction Partner: PANX1, AXIN1, UBC, FUS, OPTN, PTGIR, HLA-A, ADRB2, NUCB2, NUCB1, LAMTOR1, SLC25A12, GNAQ, GNA11, UBD, TBXA2R, GNB1, AVPR2, SUMO1, PCK1, Ric8b, GNG2, CALM1, Haus1, Trim69, Cbx1, RIC8A, TTC1, SNX13, ADCY5, CRHR1, PTGDR, TSHR, CAV3, HTR6, RGS2, ADCY6, VIPR1,
Protein Size: 394

分子量

46 kDa

基因ID

2778

NCBI登录号

NM_000516, NP_000507

UniProt

P63092

途径

Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis