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IDH3A 抗体 (N-Term)

This anti-IDH3A antibody is a 兔 多克隆 antibody detecting IDH3A in WB 和 IHC. Suitable for 人, 大鼠, 小鼠, Cow, 犬, 马, 兔, 豚鼠 和 斑马鱼. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN2775312
发货至: 中国

Quick Overview for IDH3A 抗体 (N-Term) (ABIN2775312)

抗原

See all IDH3A 抗体
IDH3A (Isocitrate Dehydrogenase 3 (NAD+) alpha (IDH3A))

适用

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人, 大鼠, 小鼠, Cow, 犬, 马, 兔, 豚鼠, 斑马鱼

宿主

  • 41
  • 4
  • 1

克隆类型

  • 43
  • 3
多克隆

标记

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This IDH3A antibody is un-conjugated

应用范围

  • 34
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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

    • 15
    • 7
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    • 1
    • 1
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    N-Term

    序列

    MKIFDAAKAP IQWEERNVTA IQGPGGKWMI PSEAKESMDK NKMGLKGPLK

    预测反应

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

    产品特性

    This is a rabbit polyclonal antibody against IDH3A. It was validated on Western Blot and immunohistochemistry.

    纯化方法

    Protein A purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N terminal region of human IDH3A
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 366 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Lin, Cheng, Tsai, Tsai, Hu, Chang, Yeh, Chen, Liao, Chang: "Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy." in: Scientific reports, Vol. 2, pp. 785, (2012) (PubMed).

  • 抗原

    IDH3A (Isocitrate Dehydrogenase 3 (NAD+) alpha (IDH3A))

    别名

    IDH3A

    背景

    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. IDH3A is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.
    Protein Interaction Partner: HUWE1, SUMO2, STAU1, UBC, MDM2, ADRB2, gag-pol, RAB4A, MBNL1, S100A16, SUCLA2, UQCRFS1P1, SUMO4, EBNA-LP, MYC, TERF2, TERF1, PSMD4, DDA1, DMWD, IDH3B, IDH3G,
    Protein Size: 366

    分子量

    40 kDa

    基因ID

    3419

    NCBI登录号

    NM_005530, NP_005521

    UniProt

    P50213
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