SH3RF1 抗体 (Middle Region)
Quick Overview for SH3RF1 抗体 (Middle Region) (ABIN2774771)
抗原
See all SH3RF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- LLKLLSGAST KRKPRVSPPA SPTLEVELGS AELPLQGAVG PELPPGGGHG
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预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against SH3RF1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human SH3RF1
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anti-SH3 Domain Containing Ring Finger 1 (SH3RF1) (AA 790-888) antibody
SH3RF1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H3 unconjugated
anti-SH3 Domain Containing Ring Finger 1 (SH3RF1) (AA 790-888) antibodySH3RF1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SH3 Domain Containing Ring Finger 1 (SH3RF1) (AA 628-742) antibodySH3RF1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-SH3 Domain Containing Ring Finger 1 (SH3RF1) (AA 719-768) antibodySH3RF1 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 兔, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 888 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))
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别名
- SH3RF1
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背景
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SH3RF1 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3RF1 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
Alias Symbols: FLJ21602, KIAA1494, POSH, RNF142, SH3MD2
Protein Interaction Partner: YWHAB, UBE2N, UBE2D3, UBE2D1, AKT2, AKT1, SIAH2, SIAH1, SH3RF2, RAC1, SEMA6A, UBC, PDCD6IP, KCNJ1, MAP4K3, MAP3K9, ADAM15, PAK2, RACGAP1, MAP3K12, MAP3K10, MAP3K11,
Protein Size: 888 -
分子量
- 93 kDa
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基因ID
- 57630
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NCBI登录号
- NM_020870, NP_065921
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UniProt
- Q7Z6J0
抗原
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