5HT1B Receptor 抗体 (N-Term)
Quick Overview for 5HT1B Receptor 抗体 (N-Term) (ABIN2774611)
抗原
See all 5HT1B Receptor (HTR1B) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV
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预测反应
- Human: 100%
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产品特性
- This is a rabbit polyclonal antibody against HTR1B. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human HTR1B
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anti-Serotonin Receptor 1B (HTR1B) (Internal Region) antibody
HTR1B 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (Internal Region) antibodyHTR1B 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (AA 1-49) antibodyHTR1B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (Cytoplasmic Domain) antibodyHTR1B 适用: 人, 大鼠, 小鼠, 犬, Bat, Cow, 豚鼠, Hamster, 兔, Pig IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (C-Term) antibodyVerified HTR1B 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (AA 33-49), (Extracellular) antibodyHTR1B 适用: 人 WB, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (AA 8-26) antibodyHTR1B 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (N-Term) antibodyHTR1B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (AA 261-310) antibodyHTR1B 适用: 人, 大鼠, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 390 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))
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别名
- HTR1B
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背景
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The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
Alias Symbols: S12, 5-HT1B, HTR1D2, HTR1DB, 5-HT1DB
Protein Interaction Partner: MDFI, HTR1D, HTR1B, HTR1A, GSTK1, NME2,
Protein Size: 390 -
分子量
- 44 kDa
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基因ID
- 3351
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NCBI登录号
- NM_000863, NP_000854
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UniProt
- P28222
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途径
- JAK/STAT Signaling, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, S100 Proteins
抗原
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